Gene Information
Gene NameHEXB
OrganismHomo sapiens (Human)
Gene Length556
Protein NamesBeta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
Target Namebeta-hexosaminidase subunit beta
Target TypeNA
Gene Age1488 ( ENSG00000049860 )
Evolutionary StageEuk+Bac
AlphaFoldDBP07686
Gene CardHEXB
Uniprot IDP07686
PfamPF00728; PF14845
In ASDno
Allosteric Predictionyes (0.362613351)
Ortholog in AnimalsAlpaca_ HEXB ( ortholog_one2one )
Dog_ HEXB ( ortholog_one2one )
GuineaPig_ HEXB ( ortholog_one2one )
Macaque_ HEXB ( ortholog_one2one )
Mouse_ Hexb ( ortholog_one2one )
Pig_ HEXB ( ortholog_one2one )
Rat_ Hexb ( ortholog_one2one )
Rabbit_ HEXB ( ortholog_one2one )
OhnologsHEXA
ParalogsHEXA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.033333(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1NOU  (X-ray  2.40A  )  1NOW  (X-ray  2.20A  )  1NP0  (X-ray  2.50A  )  1O7A  (X-ray  2.25A  )  2GJX  (X-ray  2.80A  )  2GK1  (X-ray  3.25A  )  3LMY  (X-ray  2.80A  )  5BRO  (X-ray  2.40A  ) 
DBSNP rs820878  rs11556045  rs10805890  rs1554035829  rs1554036641  rs28942073  rs121907982  rs121907985  rs121907983  rs727503960  rs121907984 
Subcellular location [CC]Lysosome {ECO:0000269|PubMed:9694901}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:P20060}.
Mouse PG classificationLPG
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