| Gene Information | |
|---|---|
| Gene Name | KIAA0586 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1533 |
| Protein Names | Protein TALPID3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000100578 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BVV6 |
| Gene Card | KIAA0586 |
| Uniprot ID | Q9BVV6 |
| Pfam | PF15324 |
| In ASD | no |
| Allosteric Prediction | no (-1.842390483) |
| Ortholog in Animals | Alpaca_ KIAA0586 ( ortholog_one2one ) Dog_ KIAA0586 ( ortholog_one2one ) GuineaPig_ KIAA0586 ( ortholog_one2one ) Macaque_ KIAA0586 ( ortholog_one2one ) Mouse_ 2700049A03Rik ( ortholog_one2one ) Pig_ KIAA0586 ( ortholog_one2one ) Rat_ 2700049A03Rik ( ortholog_one2one ) Rabbit_ KIAA0586 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (PubMed:26386044). Expressed in photoreceptor cells (at protein level) (PubMed:26386247). {ECO:0000269|PubMed:26386044, ECO:0000269|PubMed:26386247}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs772739103 rs1748986 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19144723}. Photoreceptor inner segment {ECO:0000269|PubMed:26386247}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:26386247}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26386247}. Note=Forms a ring-like structure at the extreme distal end of both mother and daughter centrioles (PubMed:24421332). In photoreceptor cells localized to the joint between the inner and outer segments, specifically localized at the mother centriole (basal body) and the adjacent centriole as well as between the two centrioles but not in the connecting cilium (PubMed:26386247). {ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:26386247}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |