| Gene Information | |
|---|---|
| Gene Name | NDRG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 394 |
| Protein Names | Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000104419 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92597 |
| Gene Card | NDRG1 |
| Uniprot ID | Q92597 |
| Pfam | PF03096 |
| In ASD | no |
| Allosteric Prediction | yes (0.382122636) |
| Ortholog in Animals | Alpaca_ NDRG1 ( ortholog_one2one ) Dog_ NDRG1 ( ortholog_one2one ) GuineaPig_ NDRG1 ( ortholog_one2one ) Macaque_ NDRG1 ( ortholog_one2one ) Mouse_ Ndrg1 ( ortholog_one2one ) Pig_ NDRG1 ( ortholog_one2one ) Rat_ Ndrg1 ( ortholog_one2one ) Rabbit_ NDRG1 ( ortholog_one2one ) |
| Ohnologs | NDRG3, NDRG4, NDRG2 |
| Paralogs | NDRG4, NDRG2, NDRG3 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression. {ECO:0000269|PubMed:12432451, ECO:0000269|PubMed:8939898, ECO:0000269|PubMed:9251681, ECO:0000269|PubMed:9605764}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6ZMM (X-ray 2.96A ) |
| DBSNP | rs2233319 rs2233328 |
| Subcellular location [CC] | Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane. |
| Mouse PG classification | NA |
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