| Gene Information | |
|---|---|
| Gene Name | HERC6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1022 |
| Protein Names | Probable E3 ubiquitin-protein ligase HERC6 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 6) (HECT-type E3 ubiquitin transferase HERC6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000138642 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IVU3 |
| Gene Card | HERC6 |
| Uniprot ID | Q8IVU3 |
| Pfam | PF00632; PF00415 |
| In ASD | no |
| Allosteric Prediction | no (-0.27705612) |
| Ortholog in Animals | Alpaca_ HERC6 ( ortholog_one2one ) Dog_ HERC6 ( ortholog_one2one ) Macaque_ HERC6 ( ortholog_one2one ) Mouse_ Herc6 ( ortholog_one2one ) Pig_ HERC6 ( ortholog_one2one ) Rat_ Herc6 ( ortholog_one2one ) Rabbit_ HERC6 ( ortholog_one2one ) |
| Ohnologs | HERC4 |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5 |
| Tissue | NA |
| Tissue Specificity | Detected in brain, heart, placenta and testis. {ECO:0000269|PubMed:15676274}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5W87 (X-ray 2.20A ) |
| DBSNP | rs7677237 rs12510688 rs17014118 rs6532068 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:15676274}. |
| Mouse PG classification | NA |
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