| Gene Information | |
|---|---|
| Gene Name | HERC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1024 |
| Protein Names | E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000138646 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9UII4 |
| Gene Card | HERC5 |
| Uniprot ID | Q9UII4 |
| Pfam | PF00632; PF00415 |
| In ASD | no |
| Allosteric Prediction | no (-0.626977608) |
| Ortholog in Animals | Alpaca_ HERC5 ( ortholog_one2one ) Dog_ HERC5 ( ortholog_one2one ) Macaque_ HERC5 ( ortholog_one2one ) Pig_ HERC5 ( ortholog_one2one ) |
| Ohnologs | HERC4 |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC6 |
| Tissue | NA |
| Tissue Specificity | Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels. {ECO:0000269|PubMed:10581175, ECO:0000269|PubMed:15331633}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17014143 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000269|PubMed:20542004}. Note=Associated with the polyribosomes, probably via the 60S subunit. |
| Mouse PG classification | NA |
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