| Gene Information | |
|---|---|
| Gene Name | CNTNAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1331 |
| Protein Names | Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000174469 ) 3 ( ENSG00000278728 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UHC6 |
| Gene Card | CNTNAP2 |
| Uniprot ID | Q9UHC6 |
| Pfam | PF00754; PF02210 |
| In ASD | no |
| Allosteric Prediction | yes (0.060538477) |
| Ortholog in Animals | Alpaca_ CNTNAP2 ( ortholog_one2one ) Dog_ CNTNAP2 ( ortholog_one2one ) GuineaPig_ CNTNAP2 ( ortholog_one2one ) Macaque_ CNTNAP2 ( ortholog_one2one ) Mouse_ Cntnap2 ( ortholog_one2one ) Pig_ CNTNAP2 ( ortholog_one2one ) Rat_ Cntnap2 ( ortholog_one2one ) Rabbit_ CNTNAP2 ( ortholog_one2one ) |
| Ohnologs | CNTNAP3, CNTNAP1, CNTNAP4, CNTNAP3B, CNTNAP5 |
| Paralogs | CNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRP1, NRXN3, EDIL3, CNTNAP1, CUBN, MEP1B, NETO1, MFGE8, PCOLCE2, NRP2, HEPHL1, F8, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2, BMP1 |
| Tissue | brain, cerebral.cortex, amygdala, hypothalamus, substantia.nigra |
| Tissue Specificity | Predominantly expressed in nervous system. {ECO:0000269|PubMed:10624965}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5Y4M (X-ray 1.31A ) |
| DBSNP | rs189731792 rs771028883 rs372345438 rs794727802 rs371839994 rs143877693 rs772179690 rs368905425 rs764412489 rs760930032 rs369867547 rs200413148 rs121908445 rs759801195 rs144003410 rs111599875 rs983036503 rs774709566 rs781236853 rs761684414 rs767821521 rs760047247 |
| Subcellular location [CC] | Membrane {ECO:0000250|UniProtKB:Q9CPW0}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CPW0}. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:Q9CPW0}. Note=Expressed in the juxtaparadonal region. {ECO:0000250|UniProtKB:Q9CPW0}. |
| Mouse PG classification | HPG |
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