| Gene Information | |
|---|---|
| Gene Name | HERC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4834 |
| Protein Names | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000128731 ) 3 ( ENSG00000276802 ) 3 ( ENSG00000277278 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | HERC2 |
| Uniprot ID | O95714 |
| Pfam | PF03256; PF11515; PF00173; PF00632; PF06701; PF00415; PF00569 |
| In ASD | no |
| Allosteric Prediction | no (-0.092666392) |
| Ortholog in Animals | GuineaPig_ HERC2 ( ortholog_one2one ) Macaque_ HERC2 ( ortholog_one2one ) Mouse_ Herc2 ( ortholog_one2one ) Pig_ HERC2 ( ortholog_one2one ) Rat_ Herc2 ( ortholog_one2one ) Rabbit_ HERC2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.005634(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KEO (NMR - ) 3KCI (X-ray 1.80A ) 4L1M (X-ray 2.60A ) 6WW3 (X-ray 2.10A ) 6WW4 (X-ray 2.25A ) 7RGW (X-ray 1.99A ) |
| DBSNP | rs397518474 |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Recruited to sites of DNA damage in response to ionizing radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis. |
| Mouse PG classification | LPG |
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