| Gene Information | |
|---|---|
| Gene Name | HERC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4861 |
| Protein Names | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000103657 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | HERC1 |
| Uniprot ID | Q15751 |
| Pfam | PF00632; PF00415; PF00622; PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.717404393) |
| Ortholog in Animals | Alpaca_ HERC1 ( ortholog_one2one ) Dog_ HERC1 ( ortholog_one2one ) GuineaPig_ HERC1 ( ortholog_one2one ) Macaque_ HERC1 ( ortholog_one2one ) Mouse_ Herc1 ( ortholog_one2one ) Pig_ HERC1 ( ortholog_one2one ) Rat_ Herc1 ( ortholog_one2one ) Rabbit_ HERC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SERGEF, RCC2, RCBTB2, RCBTB1, RCC1L, RPGR, RCCD1, RCC1, ALS2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:8861955}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.100000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4O2W (X-ray 2.00A ) 4QT6 (X-ray 1.64A ) |
| DBSNP | rs1063423 rs3764187 rs36089909 rs7162519 rs16947363 rs2255243 rs2228512 rs2228510 rs35122568 rs2228513 rs7182782 rs2229749 rs2228516 rs769677823 |
| Subcellular location [CC] | Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin-rich surface protrusions. |
| Mouse PG classification | NA |
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