| Gene Information | |
|---|---|
| Gene Name | HER2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1255 |
| Protein Names | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P04626 |
| Gene Card | ERBB2 |
| Uniprot ID | P04626 |
| Pfam | PF00757; PF14843; PF07714; PF01030 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. {ECO:0000269|PubMed:15380516}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.391370(Rat);0.112943(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1MFG (X-ray 1.25A ) 1MFL (X-ray 1.88A ) 1MW4 (NMR - ) 1N8Z (X-ray 2.52A ) 1QR1 (X-ray 2.40A ) 1S78 (X-ray 3.25A ) 2A91 (X-ray 2.50A ) 2JWA (NMR - ) 2KS1 (NMR - ) 2L4K (NMR - ) 2N2A (NMR - ) 3BE1 (X-ray 2.90A ) 3H3B (X-ray 2.45A ) 3MZW (X-ray 2.90A ) 3N85 (X-ray 3.20A ) 3PP0 (X-ray 2.25A ) 3RCD (X-ray 3.21A ) 3WLW (X-ray 3.09A ) 3WSQ (X-ray 3.50A ) 4GFU (X-ray 2.00A ) 4HRL (X-ray 2.55A ) 4HRM (X-ray 3.20A ) 4HRN (X-ray 2.65A ) 4NND (X-ray 2.50A ) 5K33 (X-ray 3.30A ) 5KWG (X-ray 4.30A ) 5MY6 (X-ray 2.25A ) 5O4G (X-ray 3.00A ) 5OB4 (NMR - ) 5TQS (X-ray 1.88A ) 6ATT (X-ray 3.77A ) 6BGT (X-ray 2.70A ) 6J71 (X-ray 2.92A ) 6LBX (X-ray 2.03A ) 6OGE (EM 4.36A ) 7JXH (X-ray 3.27A ) 7MN5 (EM 2.93A ) 7MN6 (EM 3.09A ) 7MN8 (EM 3.45A ) 7PCD (X-ray 1.77A ) |
| DBSNP | rs4252633 rs1801201 rs1136201 rs121913469 rs56366519 rs28933369 rs28933370 rs28933368 rs1058808 rs55943169 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:32381043}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:34380438}; Single-pass type I membrane protein {ECO:0000255}. Note=Internalized from the cell membrane in response to EGF stimulation. {ECO:0000269|PubMed:32381043}.; [Isoform 1]: Cell membrane {ECO:0000269|PubMed:31138794, ECO:0000269|PubMed:33497358}; Single-pass type I membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:31138794}. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). {ECO:0000269|PubMed:31138794}.; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus. |
| Mouse PG classification | NA |
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