| Gene Information | |
|---|---|
| Gene Name | HEPC |
| Organism | Homo sapiens (Human) |
| Gene Length | 84 |
| Protein Names | Hepcidin (Liver-expressed antimicrobial peptide 1) (LEAP-1) (Putative liver tumor regressor) (PLTR) [Cleaved into: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P81172 |
| Gene Card | HAMP |
| Uniprot ID | P81172 |
| Pfam | PF06446 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine and blood (PubMed:11034317). Expressed by hepatocytes (PubMed:15124018). {ECO:0000269|PubMed:11034317, ECO:0000269|PubMed:15124018}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1M4E (NMR - ) 1M4F (NMR - ) 2KEF (NMR - ) 3H0T (X-ray 1.89A ) 4QAE (X-ray 2.10A ) 6WBV (EM 2.50A ) |
| DBSNP | rs779021719 rs1374259518 rs104894696 rs1462013476 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11034317}. |
| Mouse PG classification | NA |
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