Gene Information
Gene NameGCNT4
OrganismHomo sapiens (Human)
Gene Length453
Protein NamesBeta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (EC 2.4.1.102) (Core 2-branching enzyme 3) (Core2-GlcNAc-transferase 3) (C2GnT3)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000176928 )
Evolutionary StageNA
AlphaFoldDBQ9P109
Gene CardGCNT4
Uniprot IDQ9P109
PfamPF02485
In ASDno
Allosteric Predictionno (-0.823693078)
Ortholog in AnimalsAlpaca_ GCNT4 ( ortholog_one2one )
GuineaPig_ GCNT4 ( ortholog_one2one )
Macaque_ GCNT4 ( ortholog_one2one )
Mouse_ Gcnt4 ( ortholog_one2one )
Pig_ GCNT4 ( ortholog_one2one )
Rat_ Gcnt4 ( ortholog_one2one )
Rabbit_ GCNT4 ( ortholog_one2one )
OhnologsGCNT3, GCNT1
ParalogsWSCD1, GCNT2, GCNT7, XYLT1, GCNT3, GCNT1, XYLT2, WSCD2
Tissuesmall.intestine
Tissue SpecificityPredominantly expressed in thymus. Weakly expressed in pancreas, peripheral blood leukocytes, placenta, small intestine and stomach. Barely detectable in liver, spleen, lung and lymph node. {ECO:0000269|PubMed:10753916}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs4704166  rs4704166  rs3811987 
Subcellular location [CC]Golgi apparatus membrane {ECO:0000250};
Single-pass type II membrane protein {ECO:0000250}.
Mouse PG classificationNA
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