| Gene Information | |
|---|---|
| Gene Name | MELK |
| Organism | Homo sapiens (Human) |
| Gene Length | 651 |
| Protein Names | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) |
| Target Name | maternal embryonic leucine zipper kinase |
| Target Type | Clinical trial target |
| Gene Age | 1292 ( ENSG00000165304 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14680 |
| Gene Card | MELK |
| Uniprot ID | Q14680 |
| Pfam | PF02149; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.298808416) |
| Ortholog in Animals | Alpaca_ MELK ( ortholog_one2one ) Dog_ MELK ( ortholog_one2one ) GuineaPig_ MELK ( ortholog_one2one ) Macaque_ MELK ( ortholog_one2one ) Mouse_ Melk ( ortholog_one2one ) Pig_ MELK ( ortholog_one2one ) Rat_ Melk ( ortholog_one2one ) Rabbit_ MELK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TSSK6, SNRK, SIK2, SIK3, NIM1K, NUAK2, TSSK2, TSSK4, SIK1, PRKAA2, BRSK2, NUAK1, BRSK1, HUNK, PRKAA1, TSSK1B, TSSK3 |
| Tissue | appendix, colon, brain, testis |
| Tissue Specificity | Expressed in placenta, kidney, thymus, testis, ovary and intestine. {ECO:0000269|PubMed:8724849}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4BKY (X-ray 1.83A ) 4BKZ (X-ray 2.20A ) 4BL1 (X-ray 2.60A ) 4D2P (X-ray 2.55A ) 4D2T (X-ray 2.70A ) 4D2V (X-ray 2.45A ) 4D2W (X-ray 1.92A ) 4IXP (X-ray 2.75A ) 4UMP (X-ray 2.30A ) 4UMQ (X-ray 2.60A ) 4UMR (X-ray 3.00A ) 4UMT (X-ray 1.98A ) 4UMU (X-ray 2.02A ) 5IH8 (X-ray 1.85A ) 5IH9 (X-ray 1.79A ) 5IHA (X-ray 1.96A ) 5IHC (X-ray 2.14A ) 5K00 (X-ray 1.77A ) 5M5A (X-ray 1.90A ) 5MAF (X-ray 2.80A ) 5MAG (X-ray 2.35A ) 5MAH (X-ray 2.00A ) 5MAI (X-ray 2.15A ) 5TVT (X-ray 2.28A ) 5TWL (X-ray 2.42A ) 5TWU (X-ray 2.60A ) 5TWY (X-ray 2.91A ) 5TWZ (X-ray 2.63A ) 5TX3 (X-ray 2.90A ) 6GVX (X-ray 2.24A ) 6VXR (X-ray 2.10A ) |
| DBSNP | rs35233455 rs35142210 rs34655121 rs55845414 rs144052967 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:16159311, ECO:0000269|PubMed:21145462}. |
| Mouse PG classification | NA |
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