| Gene Information | |
|---|---|
| Gene Name | OSBPL11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 747 |
| Protein Names | Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000144909 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BXB4 |
| Gene Card | OSBPL11 |
| Uniprot ID | Q9BXB4 |
| Pfam | PF01237; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-1.377776994) |
| Ortholog in Animals | Alpaca_ OSBPL11 ( ortholog_one2one ) GuineaPig_ OSBPL11 ( ortholog_one2one ) Macaque_ OSBPL11 ( ortholog_one2one ) Mouse_ Osbpl11 ( ortholog_one2one ) Pig_ OSBPL11 ( ortholog_one2one ) Rat_ Osbpl11 ( ortholog_one2one ) Rabbit_ OSBPL11 ( ortholog_one2one ) |
| Ohnologs | OSBPL9, OSBPL10 |
| Paralogs | OSBPL10, OSBPL2, OSBP2, OSBPL1A, OSBP, OSBPL8, OSBPL3, OSBPL5, OSBPL9, OSBPL6, OSBPL7 |
| Tissue | NA |
| Tissue Specificity | Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level)(PubMed:23028956). {ECO:0000269|PubMed:20599956, ECO:0000269|PubMed:23028956}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2D9X (NMR - ) |
| DBSNP | rs746035150 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000269|PubMed:20599956}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:20599956}. Note=Localizes at the Golgi-late endosome interface. |
| Mouse PG classification | NA |
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