Gene Information
Gene NameMTMR2
OrganismHomo sapiens (Human)
Gene Length643
Protein NamesMyotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000087053 )
Evolutionary StageEukaryota
AlphaFoldDBQ13614
Gene CardMTMR2
Uniprot IDQ13614
PfamPF02893; PF06602
In ASDno
Allosteric Predictionyes (0.022548988)
Ortholog in AnimalsAlpaca_ MTMR2 ( ortholog_one2one )
Dog_ MTMR2 ( ortholog_one2one )
GuineaPig_ MTMR2 ( ortholog_one2one )
Macaque_ MTMR2 ( ortholog_one2one )
Mouse_ Mtmr2 ( ortholog_one2one )
Pig_ MTMR2 ( ortholog_one2one )
Rat_ Mtmr2 ( ortholog_one2one )
Rabbit_ MTMR2 ( ortholog_one2one )
OhnologsMTMR1, MTM1
ParalogsMTMR10, MTMR7, SBF1, SBF2, MTMR9, MTM1, MTMR8, MTMR6, MTMR12, MTMR11, MTMR3, MTMR4, MTMR1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1LW3  (X-ray  2.30A  1M7R  (X-ray  2.60A  1ZSQ  (X-ray  1.82A  1ZVR  (X-ray  1.98A  5GNH  (X-ray  2.60A 
DBSNP rs3824874  rs1590983932  rs558018 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:15998640}. Early endosome membrane {ECO:0000269|PubMed:15998640, ECO:0000269|PubMed:21372139};
Peripheral membrane protein {ECO:0000269|PubMed:15998640, ECO:0000269|PubMed:21372139}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12668758}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2D1}. Endosome membrane {ECO:0000250|UniProtKB:Q9Z2D1};
Peripheral membrane protein {ECO:0000305}. Note=Partly associated with membranes (PubMed:12668758, PubMed:15998640, PubMed:21372139). Localizes to vacuoles in hypo-osmotic conditions (By similarity). {ECO:0000250|UniProtKB:Q9Z2D1, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:15998640, ECO:0000269|PubMed:21372139}.
Mouse PG classificationNA
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