Gene Information
Gene NameMYH9
OrganismHomo sapiens (Human)
Gene Length1960
Protein NamesMyosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)
Target Namemyosin-9
Target TypeNA
Gene Age544 ( ENSG00000100345 )
Evolutionary StageEukaryota
AlphaFoldDBP35579
Gene CardMYH9
Uniprot IDP35579
PfamPF00063; PF02736; PF01576
In ASDno
Allosteric Predictionyes (0.725046321)
Ortholog in AnimalsAlpaca_ MYH9 ( ortholog_one2one )
Dog_ MYH9 ( ortholog_one2one )
GuineaPig_ MYH9 ( ortholog_one2one )
Macaque_ MYH9 ( ortholog_one2one )
Mouse_ Myh9 ( ortholog_one2one )
Pig_ MYH9 ( ortholog_one2one )
Rat_ Myh9 ( ortholog_one2one )
Rabbit_ MYH9 ( ortholog_one2one )
OhnologsMYH14, MYH10, MYH11
ParalogsMYO3A, MYH10, TMF1, MYO7B, MYO1D, CCDC102B, MYH1, MYO19, MYO1C, MYH3, MYH7, MYO1A, MYO15A, MYO18A, MYO1E, MYH14, MYH2, MYH15, MYO3B, CCDC102A, MYO5A, MYO1G, MYO1H, MYO18B, MYO5C, MYO9B, MYO7A, MYH7B, MYO5B, CGNL1, CGN, MYH11, MYO16, MYO10, MYH8, MYH6, MYO9A, MYO6, MYH4, CCDC158, MYO1B, MYO1F, MYH13
TissueNA
Tissue SpecificityIn the kidney, expressed in the glomeruli. Also expressed in leukocytes. {ECO:0000269|PubMed:11752022, ECO:0000269|PubMed:1912569}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001293(Rat);0.005882(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2LNK  (NMR  -  )  3ZWH  (X-ray  1.94A  )  4CFQ  (X-ray  1.37A  )  4CFR  (X-ray  1.40A  )  4ETO  (X-ray  1.54A  ) 
DBSNP rs121913655  rs1603484047  rs121913657  rs1603483388  rs80338826  rs80338827  rs80338828  rs554332083  rs16996652  rs200901330  rs121913656  rs80338829  rs80338830  rs746956415  rs76368635  rs80338831  rs80338831  rs80338831  rs2269529  rs762773112  rs80338834 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22693546}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VDD5}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8VDD5}. Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610). {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:27331610}.
Mouse PG classificationHPG
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