| Gene Information | |
|---|---|
| Gene Name | PRSS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 247 |
| Protein Names | Serine protease 1 (EC 3.4.21.4) (Anionic trypsin I) (Anionic trypsin-I) (Beta-trypsin) (Cationic trypsinogen) (Pretrypsinogen I) (Trypsin I) (Trypsin-1) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2] |
| Target Name | cationic trypsinogen |
| Target Type | Successful target |
| Gene Age | 382 ( ENSG00000204983 ) 3 ( ENSG00000274247 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P07477 |
| Gene Card | PRSS1 |
| Uniprot ID | P07477 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.911945022) |
| Ortholog in Animals | Alpaca_ PRSS1 ( ortholog_one2one ) Dog_ PRSS2 ( ortholog_one2many ) Mouse_ Prss3 ( ortholog_many2many ) Mouse_ Try4 ( ortholog_many2many ) Mouse_ Try10 ( ortholog_many2many ) Mouse_ Prss1 ( ortholog_many2many ) Mouse_ Gm5771 ( ortholog_many2many ) Mouse_ Try5 ( ortholog_many2many ) Mouse_ Gm10334 ( ortholog_many2many ) Mouse_ Prss2 ( ortholog_many2many ) Pig_ PRSS2 ( ortholog_one2many ) Rat_ Try10 ( ortholog_many2many ) Rat_ Prss1 ( ortholog_many2many ) Rat_ Prss3 ( ortholog_many2many ) Rat_ Prss2 ( ortholog_many2many ) Rat_ Try5 ( ortholog_many2many ) |
| Ohnologs | PRSS3, KLK5 |
| Paralogs | PLAU, PRSS3, PRSS2 |
| Tissue | pancreas |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FXY (X-ray 2.15A ) 1TRN (X-ray 2.20A ) 2RA3 (X-ray 1.46A ) 4WWY (X-ray 1.70A ) 4WXV (X-ray 2.10A ) 7QE8 (X-ray 2.90A ) 7QE9 (X-ray 2.10A ) |
| DBSNP | rs202003805 rs397507442 rs111033567 rs111033566 rs111033566 rs144422014 rs111033564 rs1554499091 rs387906698 rs111033568 rs267606982 rs117497341 |
| Subcellular location [CC] | Secreted, extracellular space. |
| Mouse PG classification | NA |
| click here to return to the previous page | |