| Gene Information | |
|---|---|
| Gene Name | CTNNA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 953 |
| Protein Names | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000066032 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P26232 |
| Gene Card | CTNNA2 |
| Uniprot ID | P26232 |
| Pfam | PF01044 |
| In ASD | no |
| Allosteric Prediction | no (-0.385750619) |
| Ortholog in Animals | Alpaca_ CTNNA2 ( ortholog_one2one ) GuineaPig_ CTNNA2 ( ortholog_one2one ) Macaque_ CTNNA2 ( ortholog_one2one ) Mouse_ Ctnna2 ( ortholog_one2one ) Pig_ CTNNA2 ( ortholog_one2one ) Rat_ Ctnna2 ( ortholog_one2one ) Rabbit_ CTNNA2 ( ortholog_one2one ) |
| Ohnologs | CTNNA1, CTNNA3 |
| Paralogs | CTNNA3, CTNNA1, VCL, CTNNAL1 |
| Tissue | brain, cerebral.cortex, amygdala, brain.meninx, diencephalon, hippocampus, middle.frontal.gyrus, middle.temporal.gyrus, occipital.cortex, occipital.lobe, olfactory.apparatus, parietal.lobe, thalamus, testis |
| Tissue Specificity | Expressed in neural tissues, with strongest expression in fetal and adult brain. Expressed in the developing cortical plate and marginal zone of 20-week-old human fetal brain. {ECO:0000269|PubMed:30013181}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6DUW (X-ray 2.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q61301}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61301}; Cytoplasmic side {ECO:0000250|UniProtKB:Q61301}. Cytoplasm {ECO:0000269|PubMed:16182284}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61301}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q61301}. Cell projection, axon {ECO:0000250|UniProtKB:Q61301}. Nucleus {ECO:0000269|PubMed:16182284}. |
| Mouse PG classification | NA |
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