| Gene Information | |
|---|---|
| Gene Name | HECW2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1572 |
| Protein Names | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000138411 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9P2P5 |
| Gene Card | HECW2 |
| Uniprot ID | Q9P2P5 |
| Pfam | PF00168; PF00632; PF18436; PF16562; PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.673891) |
| Ortholog in Animals | Alpaca_ HECW2 ( ortholog_one2one ) Dog_ HECW2 ( ortholog_one2one ) GuineaPig_ HECW2 ( ortholog_one2one ) Macaque_ HECW2 ( ortholog_one2one ) Mouse_ Hecw2 ( ortholog_one2one ) Pig_ HECW2 ( ortholog_one2one ) Rat_ Hecw2 ( ortholog_one2one ) Rabbit_ HECW2 ( ortholog_one2one ) |
| Ohnologs | HECW1 |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in adult brain, lung and heart. {ECO:0000269|PubMed:12890487}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2LFE (NMR - ) |
| DBSNP | rs878854416 rs878854422 rs878854417 rs878854424 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24163370}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |