| Gene Information | |
|---|---|
| Gene Name | HCRTR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 425 |
| Protein Names | Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R) |
| Target Name | orexin receptor type 1 |
| Target Type | Clinical trial target |
| Gene Age | 244 ( ENSG00000121764 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43613 |
| Gene Card | HCRTR1 |
| Uniprot ID | O43613 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.09849675) |
| Ortholog in Animals | Alpaca_ HCRTR1 ( ortholog_one2one ) Dog_ HCRTR1 ( ortholog_one2one ) GuineaPig_ HCRTR1 ( ortholog_one2one ) Macaque_ HCRTR1 ( ortholog_one2one ) Mouse_ Hcrtr1 ( ortholog_one2one ) Pig_ HCRTR1 ( ortholog_one2one ) Rat_ Hcrtr1 ( ortholog_one2one ) Rabbit_ HCRTR1 ( ortholog_one2one ) |
| Ohnologs | NPFFR2, HCRTR2 |
| Paralogs | HCRTR2, NPFFR1, NPFFR2, CCKBR, CCKAR, OXTR, AVPR2, AVPR1B, AVPR1A, GNRHR, GALR3, GPR22, GPR150, FFAR4, GALR1, QRFPR |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4ZJ8 (X-ray 2.75A ) 4ZJC (X-ray 2.83A ) 6TO7 (X-ray 2.26A ) 6TOD (X-ray 2.11A ) 6TOS (X-ray 2.13A ) 6TOT (X-ray 2.22A ) 6TP3 (X-ray 3.04A ) 6TP4 (X-ray 3.01A ) 6TP6 (X-ray 2.34A ) 6TQ4 (X-ray 2.30A ) 6TQ6 (X-ray 2.55A ) 6TQ7 (X-ray 2.66A ) 6TQ9 (X-ray 2.65A ) 6V9S (X-ray 3.50A ) |
| DBSNP | rs144603792 rs7516785 rs41439244 rs2271933 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897}; Multi-pass membrane protein {ECO:0000269|PubMed:26950369}. |
| Mouse PG classification | NA |
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