Gene Information
Gene NameREST
OrganismHomo sapiens (Human)
Gene Length1097
Protein NamesRE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000084093 )
Evolutionary StageVertebrata
AlphaFoldDBQ13127
Gene CardREST
Uniprot IDQ13127
PfamNA
In ASDno
Allosteric Predictionyes (1.089100552)
Ortholog in AnimalsAlpaca_ REST ( ortholog_one2one )
Macaque_ REST ( ortholog_one2one )
Mouse_ Rest ( ortholog_one2one )
Rat_ Rest ( ortholog_one2one )
Rabbit_ REST ( ortholog_one2one )
OhnologsNA
ParalogsZSCAN32, ZNF641, ZNF274, ZNF131, ZSCAN5C, ZSCAN5A, ZNF518A, SCAND1, ZSCAN29, ZSCAN1, ZNF202, ZSCAN18, ZNF444, PLAG1, ZNF18, PLAGL1, ZKSCAN2, PEG3, ZSCAN5B, ZNF576, PLAGL2, ZNF496, ZNF174, OVOL1, OVOL2, ZNF446, OVOL3, ZNF770, ZNF518B
TissueNA
Tissue SpecificityExpressed in neurons of the prefrontal cortex, in hippocampal pyramidal neurons, dentate gyrus granule neurons and cerebellar Purkinje and granule neurons (at protein level) (PubMed:24670762). Expressed in dopaminergic neurons of the substantia nigra (at protein level) (PubMed:30684677). Expressed in neural progenitor cells (at protein level) (PubMed:21258371). In patients suffering from Alzheimer disease, frontotemporal dementia or dementia with Lewy bodies, decreased nuclear levels have been observed in neurons of the prefrontal cortex and the hippocampus, but not in neurons of the dentate gyrus and cerebellum (at protein level) (PubMed:24670762). In patients with Parkinson disease or dementia with Lewy bodies, decreased nuclear levels have been observed in dopaminergic neurons and in cortical neurons and localization to Lewy bodies and pale bodies was detected (at protein level) (PubMed:30684677). Expressed at higher levels in weakly invasive breast cancer cell lines and at lower levels in highly invasive breast cancer lines (at protein level) (PubMed:26053433). Ubiquitous (PubMed:8568247). Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary (PubMed:8568247). {ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:30684677, ECO:0000269|PubMed:8568247}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2CZY  (NMR  -  )  6DU2  (X-ray  2.50A  )  6DU3  (X-ray  2.58A  ) 
DBSNP rs869025312  rs2228991  rs2227902  rs2227903  rs3796529 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:16442230, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:30684677}. Cytoplasm {ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:30684677}. Note=Colocalizes with ZFP90 in the nucleus (By similarity). In response to hypoxia, there is a more pronounced increase in levels in the nucleus as compared to the cytoplasm (PubMed:27531581). In aging neurons, increased levels in the nucleus as compared to the cytoplasm (PubMed:24670762, PubMed:30684677). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:30684677}.;
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16442230}.;
[Isoform 3]: Nucleus {ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:16442230}.;
[Isoform 4]: Cytoplasm {ECO:0000269|PubMed:16442230}.
Mouse PG classificationNA
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