Gene Information
Gene NameRDH5
OrganismHomo sapiens (Human)
Gene Length318
Protein NamesRetinol dehydrogenase 5 (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (11-cis retinol dehydrogenase) (11-cis RDH) (11-cis RoDH) (9-cis retinol dehydrogenase) (9cRDH) (Short chain dehydrogenase/reductase family 9C member 5)
Target Name11-cis retinol dehydrogenase
Target TypeNA
Gene Age645 ( ENSG00000135437 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ92781
Gene CardRDH5
Uniprot IDQ92781
PfamPF00106
In ASDno
Allosteric Predictionno (-0.929252103)
Ortholog in AnimalsAlpaca_ RDH5 ( ortholog_one2one )
Dog_ RDH5 ( ortholog_one2one )
GuineaPig_ RDH5 ( ortholog_one2one )
Macaque_ RDH5 ( ortholog_one2one )
Mouse_ Rdh5 ( ortholog_one2one )
Pig_ RDH5 ( ortholog_one2one )
Rat_ Bloc1s1 ( ortholog_one2one )
Rabbit_ RDH5 ( ortholog_one2one )
OhnologsDHRS9, BDH1
ParalogsSDR9C7, HSD17B14, HSD17B7, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, WWOX, HSD17B2, DHRS3, HSD17B13, HSD17B12, SDR16C5, HSD17B1, RDH10, HSD17B10, HSD17B3, HSD17B6
Tissueadipose.tissue, bone.marrow, breast, penis, pulmonary.valve
Tissue SpecificityWidely expressed. In the eye, abundant in the retinal pigment epithelium. {ECO:0000269|PubMed:9115228, ECO:0000269|PubMed:9931293}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs3138143  rs62638195  rs759359491  rs1058635  rs62638185  rs765993603  rs377029071  rs62638187  rs104894374  rs755168439  rs758411232  rs104894373  rs781112960  rs62638191  rs780377973  rs62638193  rs62638194  rs111033593 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:11675386};
Multi-pass membrane protein {ECO:0000255};
Lumenal side {ECO:0000269|PubMed:11675386}.
Mouse PG classificationNA
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