| Gene Information | |
|---|---|
| Gene Name | HE4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 124 |
| Protein Names | WAP four-disulfide core domain protein 2 (Epididymal secretory protein E4) (Major epididymis-specific protein E4) (Putative protease inhibitor WAP5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q14508 |
| Gene Card | WFDC2 |
| Uniprot ID | Q14508 |
| Pfam | PF00095 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. {ECO:0000269|PubMed:15781627}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15781627, ECO:0000269|PubMed:23139753}. |
| Mouse PG classification | NA |
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