| Gene Information | |
|---|---|
| Gene Name | HDS |
| Organism | Homo sapiens (Human) |
| Gene Length | 333 |
| Protein Names | Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q86SQ9 |
| Gene Card | DHDDS |
| Uniprot ID | Q86SQ9 |
| Pfam | PF01255 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). Slightly expressed in heart, spleen and thymus. {ECO:0000269|PubMed:20736409}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6W2L (X-ray 2.31A ) 6Z1N (X-ray 2.30A ) 7PAX (X-ray 2.00A ) 7PAY (X-ray 2.40A ) 7PB0 (X-ray 2.30A ) 7PB1 (X-ray 2.59A ) |
| DBSNP | rs1553121073 rs147394623 rs1557447255 rs1553122926 rs3816539 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14652022}; Peripheral membrane protein {ECO:0000269|PubMed:14652022}. Note=colocalizes with calnexin. |
| Mouse PG classification | NA |
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