Gene Information

Gene Information
Gene Name	HRAS
Organism	Homo sapiens (Human)
Gene Length	189
Protein Names	GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Target Name	gtpase hras
Target Type	NA
Gene Age	645 ( ENSG00000174775 ) 3 ( ENSG00000276536 )
Evolutionary Stage	Eukaryota
AlphaFoldDB	P01112
Gene Card	HRAS
Uniprot ID	P01112
Pfam	PF00071
In ASD	yes
Allosteric Prediction	yes (0.999531316)
Ortholog in Animals	Alpaca_ HRAS ( ortholog_one2one ) Dog_ HRAS ( ortholog_one2one ) GuineaPig_ HRAS ( ortholog_one2one ) Macaque_ HRAS ( ortholog_one2one ) Mouse_ Hras ( ortholog_one2one ) Pig_ HRAS ( ortholog_one2one ) Rat_ Hras ( ortholog_one2many ) Rat_ AABR07039356.1 ( ortholog_one2many )
Ohnologs	RRAS, KRAS, NRAS
Paralogs	RRAS, RHEB, KRAS, DIRAS1, RRAS2, RAP2B, RERG, RASL12, RRAD, RIT1, DIRAS2, ERAS, NKIRAS1, RALB, RASD2, GEM, DIRAS3, MRAS, RAP2A, RASD1, REM1, NKIRAS2, RALA, RAP1A, RASL11B, RAP1B, RASL10A, RASL11A, REM2, RERGL, RIT2, RHEBL1, NRAS, RAP2C, RASL10B
Tissue	NA
Tissue Specificity	Widely expressed. {ECO:0000269\|PubMed:14500341}.
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	121P (X-ray 1.54A ) 1AA9 (NMR - ) 1AGP (X-ray 2.30A ) 1BKD (X-ray 2.80A ) 1CLU (X-ray 1.70A ) 1CRP (NMR - ) 1CRQ (NMR - ) 1CRR (NMR - ) 1CTQ (X-ray 1.26A ) 1GNP (X-ray 2.70A ) 1GNQ (X-ray 2.50A ) 1GNR (X-ray 1.85A ) 1HE8 (X-ray 3.00A ) 1IAQ (X-ray 2.90A ) 1IOZ (X-ray 2.00A ) 1JAH (X-ray 1.80A ) 1JAI (X-ray 1.80A ) 1K8R (X-ray 3.00A ) 1LF0 (X-ray 1.70A ) 1LF5 (X-ray 1.70A ) 1LFD (X-ray 2.10A ) 1NVU (X-ray 2.20A ) 1NVV (X-ray 2.18A ) 1NVW (X-ray 2.70A ) 1NVX (X-ray 3.20A ) 1P2S (X-ray 2.45A ) 1P2T (X-ray 2.00A ) 1P2U (X-ray 2.00A ) 1P2V (X-ray 2.30A ) 1PLJ (X-ray 2.80A ) 1PLK (X-ray 2.80A ) 1PLL (X-ray 2.80A ) 1Q21 (X-ray 2.20A ) 1QRA (X-ray 1.60A ) 1RVD (X-ray 1.90A ) 1WQ1 (X-ray 2.50A ) 1XCM (X-ray 1.84A ) 1XD2 (X-ray 2.70A ) 1XJ0 (X-ray 1.70A ) 1ZVQ (X-ray 2.00A ) 1ZW6 (X-ray 1.50A ) 221P (X-ray 2.30A ) 2C5L (X-ray 1.90A ) 2CE2 (X-ray 1.00A ) 2CL0 (X-ray 1.80A ) 2CL6 (X-ray 1.24A ) 2CL7 (X-ray 1.25A ) 2CLC (X-ray 1.30A ) 2CLD (X-ray 1.22A ) 2EVW (X-ray 1.05A ) 2LCF (NMR - ) 2LWI (NMR - ) 2N42 (NMR - ) 2N46 (NMR - ) 2Q21 (X-ray 2.20A ) 2QUZ (X-ray 1.49A ) 2RGA (X-ray 1.90A ) 2RGB (X-ray 1.35A ) 2RGC (X-ray 1.60A ) 2RGD (X-ray 2.00A ) 2RGE (X-ray 1.40A ) 2RGG (X-ray 1.45A ) 2UZI (X-ray 2.00A ) 2VH5 (X-ray 2.70A ) 2X1V (X-ray 1.70A ) 3DDC (X-ray 1.80A ) 3I3S (X-ray 1.36A ) 3K8Y (X-ray 1.30A ) 3K9L (X-ray 1.80A ) 3K9N (X-ray 2.00A ) 3KKM (X-ray 1.70A ) 3KKN (X-ray 2.09A ) 3KUD (X-ray 2.15A ) 3L8Y (X-ray 2.02A ) 3L8Z (X-ray 1.44A ) 3LBH (X-ray 1.85A ) 3LBI (X-ray 2.09A ) 3LBN (X-ray 1.86A ) 3LO5 (X-ray 2.57A ) 3OIU (X-ray 1.32A ) 3OIV (X-ray 1.84A ) 3OIW (X-ray 1.30A ) 3RRY (X-ray 1.60A ) 3RRZ (X-ray 1.60A ) 3RS0 (X-ray 1.40A ) 3RS2 (X-ray 1.84A ) 3RS3 (X-ray 1.52A ) 3RS4 (X-ray 1.70A ) 3RS5 (X-ray 1.68A ) 3RS7 (X-ray 1.70A ) 3RSL (X-ray 1.70A ) 3RSO (X-ray 1.60A ) 3TGP (X-ray 1.31A ) 421P (X-ray 2.20A ) 4DLR (X-ray 1.32A ) 4DLS (X-ray 1.82A ) 4DLT (X-ray 1.70A ) 4DLU (X-ray 1.60A ) 4DLV (X-ray 1.57A ) 4DLW (X-ray 1.72A ) 4DLX (X-ray 1.73A ) 4DLY (X-ray 1.57A ) 4DLZ (X-ray 1.66A ) 4DST (X-ray 2.30A ) 4DSU (X-ray 1.70A ) 4EFL (X-ray 1.90A ) 4EFM (X-ray 1.90A ) 4EFN (X-ray 2.30A ) 4G0N (X-ray 2.45A ) 4G3X (X-ray 3.25A ) 4K81 (X-ray 2.40A ) 4L9S (X-ray 1.61A ) 4L9W (X-ray 1.95A ) 4NYI (X-ray 2.96A ) 4NYJ (X-ray 2.85A ) 4NYM (X-ray 3.55A ) 4Q21 (X-ray 2.00A ) 4RSG (Neutron 1.91A ) 4URU (X-ray 2.83A ) 4URV (X-ray 2.58A ) 4URW (X-ray 2.76A ) 4URX (X-ray 2.49A ) 4URY (X-ray 2.47A ) 4URZ (X-ray 2.24A ) 4US0 (X-ray 2.17A ) 4US1 (X-ray 2.65A ) 4US2 (X-ray 2.48A ) 4XVQ (X-ray 1.89A ) 4XVR (X-ray 2.03A ) 521P (X-ray 2.60A ) 5B2Z (X-ray 1.56A ) 5B30 (X-ray 1.60A ) 5E95 (X-ray 1.40A ) 5P21 (X-ray 1.35A ) 5VBE (X-ray 1.57A ) 5VBZ (X-ray 2.20A ) 5WDO (X-ray 1.65A ) 5WDP (X-ray 1.35A ) 5WDQ (X-ray 1.25A ) 5WFO (X-ray 1.99A ) 5WFP (X-ray 2.08A ) 5WFQ (X-ray 2.26A ) 5WFR (X-ray 2.46A ) 5WPL (X-ray 2.15A ) 5X9S (X-ray 2.50A ) 5ZC6 (NMR - ) 621P (X-ray 2.40A ) 6AMB (X-ray 2.50A ) 6AXG (X-ray 3.30A ) 6BVI (X-ray 1.75A ) 6BVJ (X-ray 1.75A ) 6BVK (X-ray 1.80A ) 6BVL (X-ray 1.75A ) 6BVM (X-ray 1.80A ) 6CUO (X-ray 1.73A ) 6CUP (X-ray 1.83A ) 6CUR (X-ray 1.73A ) 6D55 (X-ray 1.68A ) 6D56 (X-ray 1.68A ) 6D59 (X-ray 1.70A ) 6D5E (X-ray 1.75A ) 6D5G (X-ray 1.92A ) 6D5H (X-ray 1.80A ) 6D5J (X-ray 1.75A ) 6D5L (X-ray 1.70A ) 6D5M (X-ray 2.08A ) 6D5V (X-ray 2.04A ) 6D5W (X-ray 2.48A ) 6DZH (X-ray 1.95A ) 6E6C (X-ray 1.90A ) 6E6P (X-ray 1.93A ) 6MQT (X-ray 1.50A ) 6NTC (X-ray 2.90A ) 6NTD (X-ray 3.15A ) 6Q21 (X-ray 1.95A ) 6V94 (X-ray 1.80A ) 6V9F (X-ray 1.85A ) 6V9J (X-ray 1.76A ) 6V9L (X-ray 1.70A ) 6V9M (X-ray 1.65A ) 6V9N (X-ray 1.65A ) 6V9O (X-ray 1.80A ) 6ZJ0 (X-ray 1.76A ) 6ZL3 (X-ray 2.03A ) 721P (X-ray 2.00A ) 7DPH (X-ray 1.54A ) 7DPJ (X-ray 1.98A ) 7JHP (X-ray 2.77A ) 7JIF (X-ray 1.76A ) 7JIG (X-ray 2.32A ) 7JIH (X-ray 1.99A ) 7JII (X-ray 1.53A ) 7L0F (X-ray 1.98A ) 7L0G (X-ray 2.54A ) 7OG9 (X-ray 1.75A ) 7OGA (X-ray 1.90A ) 7OGB (X-ray 1.85A ) 7OGC (X-ray 1.70A ) 7OGD (X-ray 1.95A ) 7OGE (X-ray 2.10A ) 7OGF (X-ray 1.80A ) 7VV8 (X-ray 1.70A ) 7VV9 (X-ray 1.60A ) 7VVG (X-ray 1.70A ) 821P (X-ray 1.50A )
DBSNP	rs104894230 rs104894229 rs104894230 rs104894229 rs104894230 rs104894228 rs104894226 rs104894228 rs121917757 rs121917758 rs28933406 rs121913233 rs121917756 rs755322824 rs104894227 rs104894231 rs121917759
Subcellular location [CC]	Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250}.; [Isoform 2]: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with RACK1 to the perinuclear region.
Mouse PG classification	NA
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