| Gene Information | |
|---|---|
| Gene Name | TMEM119 |
| Organism | Homo sapiens (Human) |
| Gene Length | 283 |
| Protein Names | Transmembrane protein 119 (Osteoblast induction factor) (OBIF) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000183160 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q4V9L6 |
| Gene Card | TMEM119 |
| Uniprot ID | Q4V9L6 |
| Pfam | PF15724 |
| In ASD | no |
| Allosteric Prediction | no (-1.199868581) |
| Ortholog in Animals | Alpaca_ TMEM119 ( ortholog_one2one ) Dog_ TMEM119 ( ortholog_one2one ) Macaque_ TMEM119 ( ortholog_one2one ) Mouse_ Tmem119 ( ortholog_one2one ) Rat_ Tmem119 ( ortholog_one2one ) Rabbit_ TMEM119 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues. {ECO:0000269|PubMed:26250788}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7975237 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20025746, ECO:0000269|PubMed:26250788}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8R138}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R138}. |
| Mouse PG classification | NA |
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