| Gene Information | |
|---|---|
| Gene Name | CD8B |
| Organism | Homo sapiens (Human) |
| Gene Length | 210 |
| Protein Names | T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000172116 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10966 |
| Gene Card | CD8B |
| Uniprot ID | P10966 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.868696093) |
| Ortholog in Animals | Alpaca_ CD8B ( ortholog_one2many ) Mouse_ Cd8b1 ( ortholog_one2many ) Rat_ Cd8b ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CD8B2 |
| Tissue | NA |
| Tissue Specificity | Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. {ECO:0000269|PubMed:8436166}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:3145196}; Single-pass type I membrane protein {ECO:0000305}. Note=Requires the partner CD8A for efficient cell surface expression (PubMed:3145196). The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation. {ECO:0000269|PubMed:10925291, ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:3145196}.; [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 3]: Secreted {ECO:0000305}.; [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 5]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 6]: Secreted {ECO:0000305}.; [Isoform 7]: Secreted {ECO:0000305}.; [Isoform 8]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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