| Gene Information | |
|---|---|
| Gene Name | TLN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2541 |
| Protein Names | Talin-1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000137076 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y490 |
| Gene Card | TLN1 |
| Uniprot ID | Q9Y490 |
| Pfam | PF16511; PF00373; PF01608; PF09141; PF08913 |
| In ASD | no |
| Allosteric Prediction | yes (0.333963082) |
| Ortholog in Animals | Alpaca_ TLN1 ( ortholog_one2one ) Dog_ TLN1 ( ortholog_one2one ) GuineaPig_ TLN1 ( ortholog_one2one ) Macaque_ TLN1 ( ortholog_one2one ) Mouse_ Tln1 ( ortholog_one2one ) Pig_ TLN1 ( ortholog_one2one ) Rat_ Tln1 ( ortholog_one2one ) Rabbit_ TLN1 ( ortholog_one2one ) |
| Ohnologs | TLN2 |
| Paralogs | TLNRD1, TLN2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.017391(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1SYQ (X-ray 2.42A ) 2MWN (NMR - ) 4DJ9 (X-ray 2.25A ) 6R9T (EM 6.20A ) |
| DBSNP | rs2295795 rs17854239 rs35642290 |
| Subcellular location [CC] | Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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