| Gene Information | |
|---|---|
| Gene Name | HDACL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 377 |
| Protein Names | Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BY41 |
| Gene Card | HDAC8 |
| Uniprot ID | Q9BY41 |
| Pfam | PF00850 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. {ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.032138(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1T64 (X-ray 1.90A ) 1T67 (X-ray 2.31A ) 1T69 (X-ray 2.91A ) 1VKG (X-ray 2.20A ) 1W22 (X-ray 2.50A ) 2V5W (X-ray 2.00A ) 2V5X (X-ray 2.25A ) 3EW8 (X-ray 1.80A ) 3EWF (X-ray 2.50A ) 3EZP (X-ray 2.65A ) 3EZT (X-ray 2.85A ) 3F06 (X-ray 2.55A ) 3F07 (X-ray 3.30A ) 3F0R (X-ray 2.54A ) 3MZ3 (X-ray 3.20A ) 3MZ4 (X-ray 1.84A ) 3MZ6 (X-ray 2.00A ) 3MZ7 (X-ray 1.90A ) 3RQD (X-ray 2.14A ) 3SFF (X-ray 2.00A ) 3SFH (X-ray 2.70A ) 4QA0 (X-ray 2.24A ) 4QA1 (X-ray 1.92A ) 4QA2 (X-ray 2.38A ) 4QA3 (X-ray 2.88A ) 4QA4 (X-ray 1.98A ) 4QA5 (X-ray 1.76A ) 4QA6 (X-ray 2.05A ) 4QA7 (X-ray 2.31A ) 4RN0 (X-ray 1.76A ) 4RN1 (X-ray 2.18A ) 4RN2 (X-ray 2.39A ) 5BWZ (X-ray 1.59A ) 5D1B (X-ray 2.90A ) 5D1C (X-ray 1.42A ) 5D1D (X-ray 2.01A ) 5DC5 (X-ray 1.94A ) 5DC6 (X-ray 1.55A ) 5DC7 (X-ray 2.30A ) 5DC8 (X-ray 1.30A ) 5FCW (X-ray 1.98A ) 5THS (X-ray 1.90A ) 5THT (X-ray 2.41A ) 5THU (X-ray 1.95A ) 5THV (X-ray 1.87A ) 5VI6 (X-ray 1.24A ) 6HSK (X-ray 2.10A ) 6ODA (X-ray 2.88A ) 6ODB (X-ray 2.70A ) 6ODC (X-ray 2.80A ) 7JVU (X-ray 1.50A ) 7JVV (X-ray 1.84A ) 7JVW (X-ray 2.40A ) |
| DBSNP | rs397515416 rs397515417 rs398122909 rs397515418 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:14701748}. Chromosome {ECO:0000269|PubMed:10748112}. Cytoplasm {ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}. Note=Excluded from the nucleoli (PubMed:10748112). Found in the cytoplasm of cells showing smooth muscle differentiation (PubMed:15772115, PubMed:16538051). {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}. |
| Mouse PG classification | NA |
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