| Gene Information | |
|---|---|
| Gene Name | C1S |
| Organism | Homo sapiens (Human) |
| Gene Length | 688 |
| Protein Names | Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain] |
| Target Name | complement c1s component |
| Target Type | Successful target |
| Gene Age | 950 ( ENSG00000182326 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P09871 |
| Gene Card | C1S |
| Uniprot ID | P09871 |
| Pfam | PF00431; PF00084; PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.897857467) |
| Ortholog in Animals | Alpaca_ C1S ( ortholog_one2one ) Dog_ C1S ( ortholog_one2one ) GuineaPig_ C1S ( ortholog_one2one ) Macaque_ C1S ( ortholog_one2one ) Mouse_ C1s1 ( ortholog_one2many ) Mouse_ C1s2 ( ortholog_one2many ) Pig_ C1S ( ortholog_one2one ) Rat_ C1s ( ortholog_one2one ) Rabbit_ C1S ( ortholog_one2one ) |
| Ohnologs | MASP2, MASP1 |
| Paralogs | HGFAC, F7, C1R, KLK10, F9, F12, F10, CFI, CFD, PRSS55, PRSS51, C1RL, HP, HPR, KLKB1, F11 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ELV (X-ray 1.70A ) 1NZI (X-ray 1.50A ) 4J1Y (X-ray 2.66A ) 4LMF (X-ray 2.92A ) 4LOR (X-ray 2.50A ) 4LOS (X-ray 2.00A ) 4LOT (X-ray 2.92A ) 6F1C (X-ray 4.20A ) 6F1H (X-ray 4.50A ) |
| DBSNP | rs12146727 rs886040975 rs2239170 rs20573 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
| click here to return to the previous page | |