| Gene Information | |
|---|---|
| Gene Name | HDAC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1084 |
| Protein Names | Histone deacetylase 4 (HD4) (EC 3.5.1.98) |
| Target Name | histone deacetylase 4 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000068024 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P56524 |
| Gene Card | HDAC4 |
| Uniprot ID | P56524 |
| Pfam | PF12203; PF00850 |
| In ASD | yes |
| Allosteric Prediction | yes (1.120623903) |
| Ortholog in Animals | Alpaca_ HDAC4 ( ortholog_one2one ) Dog_ HDAC4 ( ortholog_one2one ) GuineaPig_ HDAC4 ( ortholog_one2one ) Macaque_ HDAC4 ( ortholog_one2one ) Mouse_ Hdac4 ( ortholog_one2one ) Pig_ HDAC4 ( ortholog_one2one ) Rat_ Hdac4 ( ortholog_one2one ) |
| Ohnologs | HDAC9, HDAC7, HDAC5 |
| Paralogs | HDAC11, HDAC8, HDAC3, HDAC7, HDAC6, HDAC10, HDAC2, HDAC1, HDAC5, HDAC9 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001615(Rat);0.035(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2H8N (X-ray 2.60A ) 2O94 (X-ray 3.00A ) 2VQJ (X-ray 2.10A ) 2VQM (X-ray 1.80A ) 2VQO (X-ray 2.15A ) 2VQQ (X-ray 1.90A ) 2VQV (X-ray 3.30A ) 2VQW (X-ray 3.00A ) 3UXG (X-ray 1.85A ) 3UZD (X-ray 1.86A ) 3V31 (X-ray 1.57A ) 4CBT (X-ray 3.03A ) 4CBY (X-ray 2.72A ) 5A2S (X-ray 2.65A ) 5ZOO (X-ray 1.85A ) 5ZOP (X-ray 2.70A ) 6FYZ (X-ray 2.15A ) |
| DBSNP | rs151043798 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q6NZM9}. |
| Mouse PG classification | NA |
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