| Gene Information | |
|---|---|
| Gene Name | HDAC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 428 |
| Protein Names | Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45) |
| Target Name | histone deacetylase 3 |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000171720 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O15379 |
| Gene Card | HDAC3 |
| Uniprot ID | O15379 |
| Pfam | PF00850 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999739386) |
| Ortholog in Animals | Alpaca_ HDAC3 ( ortholog_one2one ) Dog_ HDAC3 ( ortholog_one2one ) GuineaPig_ HDAC3 ( ortholog_one2one ) Macaque_ HDAC3 ( ortholog_one2one ) Mouse_ Hdac3 ( ortholog_one2one ) Pig_ HDAC3 ( ortholog_one2one ) Rabbit_ HDAC3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HDAC4, HDAC11, HDAC8, HDAC7, HDAC6, HDAC10, HDAC2, HDAC1, HDAC5, HDAC9 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.101698(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4A69 (X-ray 2.06A ) |
| DBSNP | rs34901743 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21030595}. Cytoplasm {ECO:0000269|PubMed:25190803}. Cytoplasm, cytosol {ECO:0000269|PubMed:21030595}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). {ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:25190803}. |
| Mouse PG classification | NA |
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