| Gene Information | |
|---|---|
| Gene Name | HDAC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 488 |
| Protein Names | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) |
| Target Name | histone deacetylase 2 |
| Target Type | Clinical trial target |
| Gene Age | 1714 ( ENSG00000196591 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q92769 |
| Gene Card | HDAC2 |
| Uniprot ID | Q92769 |
| Pfam | PF00850 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000079822) |
| Ortholog in Animals | Alpaca_ HDAC2 ( ortholog_one2one ) Dog_ HDAC2 ( ortholog_one2one ) GuineaPig_ HDAC2 ( ortholog_one2one ) Macaque_ HDAC2 ( ortholog_one2one ) Mouse_ Hdac2 ( ortholog_one2one ) Pig_ HDAC2 ( ortholog_one2one ) Rat_ Hdac2 ( ortholog_one2one ) Rabbit_ HDAC2 ( ortholog_one2one ) |
| Ohnologs | HDAC1 |
| Paralogs | HDAC4, HDAC11, HDAC8, HDAC3, HDAC7, HDAC6, HDAC10, HDAC1, HDAC5, HDAC9 |
| Tissue | NA |
| Tissue Specificity | Widely expressed; lower levels in brain and lung. |
| Pharmacological Animal Models | 0.122624(Chimpanzee);0.084510(Mouse);0.113434(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3MAX (X-ray 2.05A ) 4LXZ (X-ray 1.85A ) 4LY1 (X-ray 1.57A ) 5IWG (X-ray 1.66A ) 5IX0 (X-ray 1.72A ) 6G3O (X-ray 2.27A ) 6WBW (X-ray 1.46A ) 6WBZ (X-ray 1.32A ) 6WHN (X-ray 1.54A ) 6WHO (X-ray 2.20A ) 6WHQ (X-ray 2.35A ) 6WHZ (X-ray 2.90A ) 6WI3 (X-ray 2.35A ) 6XDM (X-ray 1.56A ) 6XEB (X-ray 1.50A ) 6XEC (X-ray 1.70A ) 7JS8 (X-ray 1.63A ) 7KBG (X-ray 1.26A ) 7KBH (X-ray 2.68A ) 7LTG (X-ray 1.80A ) 7LTK (X-ray 1.59A ) 7LTL (X-ray 1.49A ) 7MOS (X-ray 1.70A ) 7MOT (X-ray 1.54A ) 7MOX (X-ray 1.69A ) 7MOY (X-ray 1.78A ) 7MOZ (X-ray 1.54A ) |
| DBSNP | rs1042903 rs17852888 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:24970816}. Cytoplasm {ECO:0000269|PubMed:24970816}. |
| Mouse PG classification | NA |
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