| Gene Information | |
|---|---|
| Gene Name | CSNK1A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 337 |
| Protein Names | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) |
| Target Name | casein kinase i isoform alpha |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000113712 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P48729 |
| Gene Card | CSNK1A1 |
| Uniprot ID | P48729 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.639123924) |
| Ortholog in Animals | Alpaca_ CSNK1A1 ( ortholog_one2one ) Dog_ CSNK1A1 ( ortholog_one2one ) GuineaPig_ CSNK1A1 ( ortholog_one2one ) Macaque_ CSNK1A1 ( ortholog_one2one ) Mouse_ Csnk1a1 ( ortholog_one2one ) Pig_ CSNK1A1 ( ortholog_one2one ) Rat_ Csnk1a1 ( ortholog_one2one ) Rabbit_ CSNK1A1 ( ortholog_one2one ) |
| Ohnologs | CSNK1A1L |
| Paralogs | CSNK1G3, TTBK2, VRK3, CSNK1A1L, VRK1, CSNK1G1, CDC7, CSNK1G2, CSNK1E, CSNK1D, VRK2, TTBK1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5FQD (X-ray 2.45A ) 6GZD (X-ray 2.28A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:1409656}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:1409656}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:1409656}. Nucleus speckle {ECO:0000303|PubMed:18305108}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BK63}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8BK63}. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). {ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:23902688}. |
| Mouse PG classification | NA |
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