| Gene Information | |
|---|---|
| Gene Name | HCKID |
| Organism | Homo sapiens (Human) |
| Gene Length | 415 |
| Protein Names | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P48730 |
| Gene Card | CSNK1D |
| Uniprot ID | P48730 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes. {ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:16027726}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001615(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3UYS (X-ray 2.30A ) 3UYT (X-ray 2.00A ) 3UZP (X-ray 1.94A ) 4HGT (X-ray 1.80A ) 4HNF (X-ray 2.07A ) 4KB8 (X-ray 1.95A ) 4KBA (X-ray 1.98A ) 4KBC (X-ray 1.98A ) 4KBK (X-ray 2.10A ) 4TN6 (X-ray 2.41A ) 4TW9 (X-ray 2.40A ) 4TWC (X-ray 1.70A ) 5IH4 (X-ray 1.90A ) 5IH5 (X-ray 2.25A ) 5IH6 (X-ray 2.30A ) 5MQV (X-ray 2.15A ) 5OKT (X-ray 2.13A ) 5W4W (X-ray 1.99A ) 6F1W (X-ray 1.86A ) 6F26 (X-ray 1.83A ) 6GZM (X-ray 1.59A ) 6HMP (X-ray 2.04A ) 6HMR (X-ray 1.78A ) 6PXN (X-ray 1.55A ) 6PXO (X-ray 2.00A ) 6PXP (X-ray 2.35A ) 6RCG (X-ray 1.40A ) 6RCH (X-ray 1.45A ) 6RU6 (X-ray 2.05A ) 6RU7 (X-ray 2.08A ) 6RU8 (X-ray 1.92A ) 7P7F (X-ray 1.96A ) 7P7G (X-ray 1.70A ) 7P7H (X-ray 2.40A ) |
| DBSNP | rs104894561 rs397514693 rs56124628 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity. |
| Mouse PG classification | NA |
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