| Gene Information | |
|---|---|
| Gene Name | HCK |
| Organism | Homo sapiens (Human) |
| Gene Length | 526 |
| Protein Names | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) |
| Target Name | tyrosine-protein kinase hck |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000101336 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P08631 |
| Gene Card | HCK |
| Uniprot ID | P08631 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (1.13575949) |
| Ortholog in Animals | Alpaca_ HCK ( ortholog_one2one ) Dog_ HCK ( ortholog_one2one ) GuineaPig_ HCK ( ortholog_one2one ) Macaque_ HCK ( ortholog_one2one ) Mouse_ Hck ( ortholog_one2one ) Pig_ HCK ( ortholog_one2one ) Rat_ Hck ( ortholog_one2one ) Rabbit_ HCK ( ortholog_one2one ) |
| Ohnologs | FGR, FYN, FRK, BLK, YES1, LCK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, ABL1, ABL2, FYN, PTK6 |
| Tissue | whole.blood |
| Tissue Specificity | Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil. {ECO:0000269|PubMed:3453117, ECO:0000269|PubMed:8064233, ECO:0000269|PubMed:8995234}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AD5 (X-ray 2.60A ) 1BU1 (X-ray 2.60A ) 1QCF (X-ray 2.00A ) 2C0I (X-ray 2.30A ) 2C0O (X-ray 2.85A ) 2C0T (X-ray 2.15A ) 2HCK (X-ray 3.00A ) 2HK5 (X-ray 2.00A ) 2OI3 (NMR - ) 2OJ2 (NMR - ) 3HCK (NMR - ) 3NHN (X-ray 2.61A ) 3RBB (X-ray 2.35A ) 3REA (X-ray 2.00A ) 3REB (X-ray 3.45A ) 3VRY (X-ray 2.48A ) 3VRZ (X-ray 2.22A ) 3VS0 (X-ray 2.93A ) 3VS1 (X-ray 2.46A ) 3VS2 (X-ray 2.61A ) 3VS3 (X-ray 2.17A ) 3VS4 (X-ray 2.75A ) 3VS5 (X-ray 2.85A ) 3VS6 (X-ray 2.37A ) 3VS7 (X-ray 3.00A ) 4HCK (NMR - ) 4LUD (X-ray 2.85A ) 4LUE (X-ray 3.04A ) 4ORZ (X-ray 2.00A ) 4U5W (X-ray 1.86A ) 5H09 (X-ray 1.95A ) 5H0B (X-ray 1.65A ) 5H0E (X-ray 2.10A ) 5H0G (X-ray 1.80A ) 5H0H (X-ray 1.72A ) 5HCK (NMR - ) 5NUH (X-ray 2.78A ) 5ZJ6 (X-ray 1.70A ) |
| DBSNP | rs56029200 rs55722810 rs17093828 |
| Subcellular location [CC] | [Isoform 1]: Lysosome. Membrane; Lipid-anchor. Cell projection, podosome membrane; Lipid-anchor. Cytoplasm, cytosol. Note=Associated with specialized secretory lysosomes called azurophil granules. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated.; [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11904303}; Lipid-anchor {ECO:0000269|PubMed:11904303}. Membrane, caveola {ECO:0000269|PubMed:11904303}; Lipid-anchor {ECO:0000269|PubMed:11904303}. Cell junction, focal adhesion {ECO:0000269|PubMed:11904303}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11904303}. Golgi apparatus {ECO:0000269|PubMed:11904303}. Cytoplasmic vesicle {ECO:0000269|PubMed:11904303}. Lysosome {ECO:0000269|PubMed:11904303}. Nucleus {ECO:0000269|PubMed:11904303}. Note=20% of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions.; Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol. |
| Mouse PG classification | NA |
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