| Gene Information | |
|---|---|
| Gene Name | HCFC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2035 |
| Protein Names | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000172534 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P51610 |
| Gene Card | HCFC1 |
| Uniprot ID | P51610 |
| Pfam | PF01344 |
| In ASD | no |
| Allosteric Prediction | yes (0.078724576) |
| Ortholog in Animals | Alpaca_ HCFC1 ( ortholog_one2many ) Dog_ HCFC1 ( ortholog_one2one ) Macaque_ HCFC1 ( ortholog_one2one ) Mouse_ Hcfc1 ( ortholog_one2one ) Pig_ HCFC1 ( ortholog_one2one ) Rat_ Hcfc1 ( ortholog_one2one ) Rabbit_ HCFC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HCFC2, KLHDC4, FBXO42, KLHDC2, KLHDC3, KLHDC1, KLHDC9, KLHDC10, RABEPK, LZTR1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in fetal tissues and the adult kidney. Present in all tissues tested. {ECO:0000269|PubMed:9389645}. |
| Pharmacological Animal Models | 0.017880(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4GO6 (X-ray 2.70A ) 4N39 (X-ray 1.76A ) 4N3A (X-ray 1.88A ) 4N3B (X-ray 2.17A ) 4N3C (X-ray 2.55A ) 5LWV (X-ray 1.90A ) 6MA1 (X-ray 2.75A ) 6MA2 (X-ray 2.10A ) 6MA3 (X-ray 2.00A ) 6MA4 (X-ray 2.00A ) 6MA5 (X-ray 2.00A ) |
| DBSNP | rs318240758 rs1051152 rs6643651 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12235138}. Nucleus {ECO:0000269|PubMed:10623756, ECO:0000269|PubMed:12235138, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21285374, ECO:0000269|PubMed:23629655}. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm (PubMed:12235138). Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER. {ECO:0000269|PubMed:12235138}. |
| Mouse PG classification | NA |
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