Gene Information
Gene NameHCF1
OrganismHomo sapiens (Human)
Gene Length2035
Protein NamesHost cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP51610
Gene CardHCFC1
Uniprot IDP51610
PfamPF01344
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityHighly expressed in fetal tissues and the adult kidney. Present in all tissues tested. {ECO:0000269|PubMed:9389645}.
Pharmacological Animal Models0.017880(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4GO6  (X-ray  2.70A  )  4N39  (X-ray  1.76A  )  4N3A  (X-ray  1.88A  )  4N3B  (X-ray  2.17A  )  4N3C  (X-ray  2.55A  )  5LWV  (X-ray  1.90A  )  6MA1  (X-ray  2.75A  )  6MA2  (X-ray  2.10A  )  6MA3  (X-ray  2.00A  )  6MA4  (X-ray  2.00A  )  6MA5  (X-ray  2.00A  ) 
DBSNP rs318240758  rs1051152  rs6643651 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:12235138}. Nucleus {ECO:0000269|PubMed:10623756, ECO:0000269|PubMed:12235138, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21285374, ECO:0000269|PubMed:23629655}. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm (PubMed:12235138). Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER. {ECO:0000269|PubMed:12235138}.
Mouse PG classificationNA
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