| Gene Information | |
|---|---|
| Gene Name | APEX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 518 |
| Protein Names | DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000169188 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UBZ4 |
| Gene Card | APEX2 |
| Uniprot ID | Q9UBZ4 |
| Pfam | PF03372; PF06839 |
| In ASD | no |
| Allosteric Prediction | no (-0.647324221) |
| Ortholog in Animals | Alpaca_ APEX2 ( ortholog_one2one ) Dog_ APEX2 ( ortholog_one2one ) GuineaPig_ APEX2 ( ortholog_one2one ) Macaque_ APEX2 ( ortholog_one2one ) Mouse_ Apex2 ( ortholog_one2one ) Pig_ APEX2 ( ortholog_one2one ) Rat_ Apex2 ( ortholog_one2many ) Rat_ Apex2l1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | APEX1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain and kidney. Weakly expressed in the fetal brain. {ECO:0000269|PubMed:11376153}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2301416 rs2301416 rs145122391 rs201964062 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Mitochondrion {ECO:0000305}. Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. |
| Mouse PG classification | NA |
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