| Gene Information | |
|---|---|
| Gene Name | MEPE |
| Organism | Homo sapiens (Human) |
| Gene Length | 525 |
| Protein Names | Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) (OF45) (Osteoregulin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000152595 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9NQ76 |
| Gene Card | MEPE |
| Uniprot ID | Q9NQ76 |
| Pfam | PF07175 |
| In ASD | no |
| Allosteric Prediction | no (-0.071552558) |
| Ortholog in Animals | Alpaca_ MEPE ( ortholog_one2one ) Dog_ MEPE ( ortholog_one2one ) Macaque_ MEPE ( ortholog_one2one ) Mouse_ Mepe ( ortholog_one2one ) Pig_ MEPE ( ortholog_one2one ) Rat_ Mepe ( ortholog_one2one ) Rabbit_ MEPE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | bone.marrow |
| Tissue Specificity | Expressed by osteoblasts (PubMed:10945470, PubMed:11414762, PubMed:15108058). Expressed by stem cells in dental pulp (PubMed:15153459). Expressed by mesenchymal cells in dental papilla and dental pulp (PubMed:18547474, PubMed:22341070). Expressed in teeth, specifically in decidious dentin (PubMed:20581062). Expressed in ondotoblasts (PubMed:12489176). Expressed in salivary glands (PubMed:15329369). Secreted from oncogenic hypophosphatemic tumors (PubMed:11414762). {ECO:0000269|PubMed:10945470, ECO:0000269|PubMed:11414762, ECO:0000269|PubMed:12489176, ECO:0000269|PubMed:15108058, ECO:0000269|PubMed:15153459, ECO:0000269|PubMed:15329369, ECO:0000269|PubMed:18547474, ECO:0000269|PubMed:20581062, ECO:0000269|PubMed:22341070}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17013285 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11414762, ECO:0000269|PubMed:15108058}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |