| Gene Information | |
|---|---|
| Gene Name | HBEGF |
| Organism | Homo sapiens (Human) |
| Gene Length | 208 |
| Protein Names | Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)] |
| Target Name | proheparin-binding egf-like growth factor |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000113070 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q99075 |
| Gene Card | HBEGF |
| Uniprot ID | Q99075 |
| Pfam | PF00008 |
| In ASD | no |
| Allosteric Prediction | yes (0.292085794) |
| Ortholog in Animals | Alpaca_ HBEGF ( ortholog_one2one ) Dog_ HBEGF ( ortholog_one2one ) GuineaPig_ HBEGF ( ortholog_one2one ) Macaque_ HBEGF ( ortholog_one2one ) Mouse_ Hbegf ( ortholog_one2one ) Pig_ HBEGF ( ortholog_one2one ) Rat_ Hbegf ( ortholog_one2one ) Rabbit_ HBEGF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EREG, BTC, AREG, EPGN, TGFA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1XDT (X-ray 2.65A ) 2M8S (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
| click here to return to the previous page | |