| Gene Information | |
|---|---|
| Gene Name | TMEM106B |
| Organism | Homo sapiens (Human) |
| Gene Length | 274 |
| Protein Names | Transmembrane protein 106B |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000106460 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NUM4 |
| Gene Card | TMEM106B |
| Uniprot ID | Q9NUM4 |
| Pfam | PF07092 |
| In ASD | no |
| Allosteric Prediction | no (-1.39596056) |
| Ortholog in Animals | Alpaca_ TMEM106B ( ortholog_one2one ) Dog_ TMEM106B ( ortholog_one2one ) GuineaPig_ TMEM106B ( ortholog_one2one ) Macaque_ TMEM106B ( ortholog_one2one ) Mouse_ Tmem106b ( ortholog_one2one ) Pig_ TMEM106B ( ortholog_one2one ) Rat_ Tmem106b ( ortholog_one2one ) Rabbit_ TMEM106B ( ortholog_one2one ) |
| Ohnologs | TMEM106C, TMEM106A |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the brain, including in the frontal cortex (at protein level) (PubMed:35247328, PubMed:35344985). Expressed in lung epithelial cels (PubMed:33686287). {ECO:0000269|PubMed:33686287, ECO:0000269|PubMed:35247328, ECO:0000269|PubMed:35344985}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7QVC (EM 2.64A ) 7QVF (EM 3.64A ) 7QWG (EM 3.38A ) 7QWL (EM 3.47A ) 7QWM (EM 2.76A ) 7SAQ (EM 2.90A ) 7SAR (EM 3.20A ) 7SAS (EM 3.70A ) 7U10 (EM 3.00A ) 7U11 (EM 3.20A ) 7U12 (EM 3.50A ) 7U13 (EM 2.90A ) 7U14 (EM 4.50A ) 7U15 (EM 3.00A ) 7U16 (EM 2.70A ) 7U17 (EM 3.00A ) 7X83 (EM 3.40A ) 7X84 (EM 3.00A ) |
| DBSNP | rs3173615 rs1554310600 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864}; Single-pass type II membrane protein {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864}. Lysosome membrane {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:25066864}; Single-pass type II membrane protein {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864}. Note=Colocalizes with LAMP1. {ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:25066864}. |
| Mouse PG classification | NA |
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