| Gene Information | |
|---|---|
| Gene Name | AMFR |
| Organism | Homo sapiens (Human) |
| Gene Length | 643 |
| Protein Names | E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000159461 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UKV5 |
| Gene Card | AMFR |
| Uniprot ID | Q9UKV5 |
| Pfam | PF02845; PF18442; PF13639 |
| In ASD | no |
| Allosteric Prediction | yes (0.154289545) |
| Ortholog in Animals | Alpaca_ AMFR ( ortholog_one2one ) Dog_ AMFR ( ortholog_one2one ) GuineaPig_ AMFR ( ortholog_one2one ) Macaque_ AMFR ( ortholog_one2one ) Mouse_ Amfr ( ortholog_one2one ) Pig_ AMFR ( ortholog_one2one ) Rat_ Amfr ( ortholog_one2one ) Rabbit_ AMFR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNF139, SYVN1, RNF145, DZIP3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EJS (NMR - ) 2LVN (NMR - ) 2LVO (NMR - ) 2LVP (NMR - ) 2LVQ (NMR - ) 2LXH (NMR - ) 2LXP (NMR - ) 3FSH (X-ray 2.76A ) 3H8K (X-ray 1.80A ) 3TIW (X-ray 1.80A ) 4G3O (X-ray 1.60A ) 4LAD (X-ray 2.30A ) |
| DBSNP | rs373191257 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:22728137}; Multi-pass membrane protein {ECO:0000269|PubMed:11724934}. Note=Palmitoylation promotes localization to the peripheral endoplasmic reticulum. {ECO:0000269|PubMed:22728137}. |
| Mouse PG classification | NA |
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