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Gene Information
Gene Name
HBB
Organism
Homo sapiens (Human)
Gene Length
147
Protein Names
Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]
Target Name
hemoglobin subunit beta
Target Type
Clinical trial target
Gene Age
78 ( ENSG00000244734 )
Evolutionary Stage
Vertebrata
AlphaFoldDB
P68871
Gene Card
HBB
Uniprot ID
P68871
Pfam
PF00042
In ASD
yes
Allosteric Prediction
yes (0.738747944)
Ortholog in Animals
Alpaca_ HBB ( ortholog_one2one )
Ohnologs
NA
Paralogs
CYGB, HBA2, HBA1, HBG2, HBG1, HBQ1, HBE1, HBM, HBZ, MB, HBD
Tissue
NA
Tissue Specificity
Red blood cells. {ECO:0000269|PubMed:6539334}.
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1A00
(X-ray
2.00A
)
1A01
(X-ray
1.80A
)
1A0U
(X-ray
2.14A
)
1A0Z
(X-ray
2.00A
)
1A3N
(X-ray
1.80A
)
1A3O
(X-ray
1.80A
)
1ABW
(X-ray
2.00A
)
1ABY
(X-ray
2.60A
)
1AJ9
(X-ray
2.20A
)
1B86
(X-ray
2.50A
)
1BAB
(X-ray
1.50A
)
1BBB
(X-ray
1.70A
)
1BIJ
(X-ray
2.30A
)
1BUW
(X-ray
1.90A
)
1BZ0
(X-ray
1.50A
)
1BZ1
(X-ray
1.59A
)
1BZZ
(X-ray
1.59A
)
1C7B
(X-ray
1.80A
)
1C7C
(X-ray
1.80A
)
1C7D
(X-ray
1.80A
)
1CBL
(X-ray
1.80A
)
1CBM
(X-ray
1.74A
)
1CH4
(X-ray
2.50A
)
1CLS
(X-ray
1.90A
)
1CMY
(X-ray
3.00A
)
1COH
(X-ray
2.90A
)
1DKE
(X-ray
2.10A
)
1DXT
(X-ray
1.70A
)
1DXU
(X-ray
1.70A
)
1DXV
(X-ray
1.70A
)
1FN3
(X-ray
2.48A
)
1G9V
(X-ray
1.85A
)
1GBU
(X-ray
1.80A
)
1GBV
(X-ray
2.00A
)
1GLI
(X-ray
2.50A
)
1GZX
(X-ray
2.10A
)
1HAB
(X-ray
2.30A
)
1HAC
(X-ray
2.60A
)
1HBA
(X-ray
2.10A
)
1HBB
(X-ray
1.90A
)
1HBS
(X-ray
3.00A
)
1HCO
(X-ray
2.70A
)
1HDB
(X-ray
2.20A
)
1HGA
(X-ray
2.10A
)
1HGB
(X-ray
2.10A
)
1HGC
(X-ray
2.10A
)
1HHO
(X-ray
2.10A
)
1IRD
(X-ray
1.25A
)
1J3Y
(X-ray
1.55A
)
1J3Z
(X-ray
1.60A
)
1J40
(X-ray
1.45A
)
1J41
(X-ray
1.45A
)
1J7S
(X-ray
2.20A
)
1J7W
(X-ray
2.00A
)
1J7Y
(X-ray
1.70A
)
1JY7
(X-ray
3.20A
)
1K0Y
(X-ray
1.87A
)
1K1K
(X-ray
2.00A
)
1KD2
(X-ray
1.87A
)
1LFL
(X-ray
2.70A
)
1LFQ
(X-ray
2.60A
)
1LFT
(X-ray
2.60A
)
1LFV
(X-ray
2.80A
)
1LFY
(X-ray
3.30A
)
1LFZ
(X-ray
3.10A
)
1LJW
(X-ray
2.16A
)
1M9P
(X-ray
2.10A
)
1MKO
(X-ray
2.18A
)
1NEJ
(X-ray
2.10A
)
1NIH
(X-ray
2.60A
)
1NQP
(X-ray
1.73A
)
1O1I
(X-ray
2.30A
)
1O1J
(X-ray
1.90A
)
1O1K
(X-ray
2.00A
)
1O1L
(X-ray
1.80A
)
1O1M
(X-ray
1.85A
)
1O1N
(X-ray
1.80A
)
1O1O
(X-ray
1.80A
)
1O1P
(X-ray
1.80A
)
1QI8
(X-ray
1.80A
)
1QSH
(X-ray
1.70A
)
1QSI
(X-ray
1.70A
)
1QXD
(X-ray
2.25A
)
1QXE
(X-ray
1.85A
)
1R1X
(X-ray
2.15A
)
1R1Y
(X-ray
1.80A
)
1RPS
(X-ray
2.11A
)
1RQ3
(X-ray
1.91A
)
1RQ4
(X-ray
2.11A
)
1RQA
(X-ray
2.11A
)
1RVW
(X-ray
2.50A
)
1SDK
(X-ray
1.80A
)
1SDL
(X-ray
1.80A
)
1THB
(X-ray
1.50A
)
1UIW
(X-ray
1.50A
)
1VWT
(X-ray
1.90A
)
1XXT
(X-ray
1.91A
)
1XY0
(X-ray
1.99A
)
1XYE
(X-ray
2.13A
)
1XZ2
(X-ray
1.90A
)
1XZ4
(X-ray
2.00A
)
1XZ5
(X-ray
2.11A
)
1XZ7
(X-ray
1.90A
)
1XZU
(X-ray
2.16A
)
1XZV
(X-ray
2.11A
)
1Y09
(X-ray
2.25A
)
1Y0A
(X-ray
2.22A
)
1Y0C
(X-ray
2.30A
)
1Y0D
(X-ray
2.10A
)
1Y0T
(X-ray
2.14A
)
1Y0W
(X-ray
2.14A
)
1Y22
(X-ray
2.16A
)
1Y2Z
(X-ray
2.07A
)
1Y31
(X-ray
2.13A
)
1Y35
(X-ray
2.12A
)
1Y45
(X-ray
2.00A
)
1Y46
(X-ray
2.22A
)
1Y4B
(X-ray
2.10A
)
1Y4F
(X-ray
2.00A
)
1Y4G
(X-ray
1.91A
)
1Y4P
(X-ray
1.98A
)
1Y4Q
(X-ray
2.11A
)
1Y4R
(X-ray
2.22A
)
1Y4V
(X-ray
1.84A
)
1Y5F
(X-ray
2.14A
)
1Y5J
(X-ray
2.03A
)
1Y5K
(X-ray
2.20A
)
1Y7C
(X-ray
2.10A
)
1Y7D
(X-ray
1.90A
)
1Y7G
(X-ray
2.10A
)
1Y7Z
(X-ray
1.98A
)
1Y83
(X-ray
1.90A
)
1Y85
(X-ray
2.13A
)
1Y8W
(X-ray
2.90A
)
1YDZ
(X-ray
3.30A
)
1YE0
(X-ray
2.50A
)
1YE1
(X-ray
4.50A
)
1YE2
(X-ray
1.80A
)
1YEN
(X-ray
2.80A
)
1YEO
(X-ray
2.22A
)
1YEQ
(X-ray
2.75A
)
1YEU
(X-ray
2.12A
)
1YEV
(X-ray
2.11A
)
1YFF
(X-ray
2.40A
)
1YG5
(X-ray
2.70A
)
1YGD
(X-ray
2.73A
)
1YGF
(X-ray
2.70A
)
1YH9
(X-ray
2.20A
)
1YHE
(X-ray
2.10A
)
1YHR
(X-ray
2.60A
)
1YIE
(X-ray
2.40A
)
1YIH
(X-ray
2.00A
)
1YVQ
(X-ray
1.80A
)
1YVT
(X-ray
1.80A
)
1YZI
(X-ray
2.07A
)
2D5Z
(X-ray
1.45A
)
2D60
(X-ray
1.70A
)
2DN1
(X-ray
1.25A
)
2DN2
(X-ray
1.25A
)
2DN3
(X-ray
1.25A
)
2DXM
(Neutron
2.10A
)
2H35
(NMR
-
)
2HBC
(X-ray
2.10A
)
2HBD
(X-ray
2.20A
)
2HBE
(X-ray
2.00A
)
2HBF
(X-ray
2.20A
)
2HBS
(X-ray
2.05A
)
2HCO
(X-ray
2.70A
)
2HHB
(X-ray
1.74A
)
2HHD
(X-ray
2.20A
)
2HHE
(X-ray
2.20A
)
2M6Z
(NMR
-
)
2W6V
(X-ray
1.80A
)
2W72
(X-ray
1.07A
)
2YRS
(X-ray
2.30A
)
3B75
(X-ray
2.30A
)
3D17
(X-ray
2.80A
)
3D7O
(X-ray
1.80A
)
3DUT
(X-ray
1.55A
)
3HHB
(X-ray
1.74A
)
3HXN
(X-ray
2.00A
)
3IC0
(X-ray
1.80A
)
3IC2
(X-ray
2.40A
)
3KMF
(Neutron
2.00A
)
3NL7
(X-ray
1.80A
)
3NMM
(X-ray
1.60A
)
3ODQ
(X-ray
3.10A
)
3ONZ
(X-ray
2.09A
)
3OO4
(X-ray
1.90A
)
3OO5
(X-ray
2.10A
)
3P5Q
(X-ray
2.00A
)
3QJB
(X-ray
1.80A
)
3QJC
(X-ray
2.00A
)
3QJD
(X-ray
1.56A
)
3QJE
(X-ray
1.80A
)
3R5I
(X-ray
2.20A
)
3S65
(X-ray
1.80A
)
3S66
(X-ray
1.40A
)
3SZK
(X-ray
3.01A
)
3W4U
(X-ray
1.95A
)
3WCP
(X-ray
1.94A
)
3WHM
(X-ray
1.85A
)
4FC3
(X-ray
2.26A
)
4HHB
(X-ray
1.74A
)
4IJ2
(X-ray
4.24A
)
4L7Y
(X-ray
1.80A
)
4M4A
(X-ray
2.05A
)
4M4B
(X-ray
2.00A
)
4MQC
(X-ray
2.20A
)
4MQG
(X-ray
1.68A
)
4MQH
(X-ray
2.50A
)
4MQI
(X-ray
1.92A
)
4N7N
(X-ray
2.75A
)
4N7O
(X-ray
2.50A
)
4N7P
(X-ray
2.81A
)
4N8T
(X-ray
1.90A
)
4NI0
(X-ray
2.15A
)
4NI1
(X-ray
1.90A
)
4ROL
(X-ray
1.70A
)
4ROM
(X-ray
1.90A
)
4WJG
(X-ray
3.10A
)
4X0L
(X-ray
2.05A
)
4XS0
(X-ray
2.55A
)
5E29
(X-ray
1.85A
)
5E6E
(X-ray
1.76A
)
5E83
(X-ray
1.80A
)
5EE4
(X-ray
2.30A
)
5HU6
(X-ray
2.90A
)
5HY8
(X-ray
2.30A
)
5JDO
(X-ray
3.20A
)
5KDQ
(X-ray
2.15A
)
5KSI
(X-ray
1.80A
)
5KSJ
(X-ray
2.40A
)
5NI1
(EM
3.20A
)
5SW7
(X-ray
1.85A
)
5U3I
(X-ray
1.95A
)
5UCU
(X-ray
1.80A
)
5UFJ
(X-ray
2.05A
)
5URC
(X-ray
1.85A
)
5VMM
(X-ray
3.60A
)
5WOG
(X-ray
1.54A
)
5WOH
(X-ray
1.58A
)
5X2R
(X-ray
2.70A
)
5X2S
(X-ray
2.39A
)
5X2T
(X-ray
2.64A
)
5X2U
(X-ray
2.53A
)
6BB5
(X-ray
2.28A
)
6BNR
(X-ray
1.95A
)
6BWP
(X-ray
1.70A
)
6BWU
(X-ray
2.00A
)
6DI4
(X-ray
1.90A
)
6FQF
(X-ray
2.10A
)
6HAL
(X-ray
2.20A
)
6HBW
(X-ray
2.00A
)
6HK2
(X-ray
1.55A
)
6KA9
(X-ray
1.40A
)
6KAE
(X-ray
1.45A
)
6KAH
(X-ray
1.45A
)
6KAI
(X-ray
1.45A
)
6KAO
(X-ray
1.40A
)
6KAP
(X-ray
1.45A
)
6KAQ
(X-ray
1.50A
)
6KAR
(X-ray
1.60A
)
6KAS
(X-ray
1.65A
)
6KAT
(X-ray
1.70A
)
6KAU
(X-ray
1.60A
)
6KAV
(X-ray
1.70A
)
6KYE
(X-ray
2.28A
)
6L5V
(X-ray
1.45A
)
6L5W
(X-ray
1.50A
)
6L5X
(X-ray
1.65A
)
6L5Y
(X-ray
1.65A
)
6LCW
(X-ray
1.40A
)
6LCX
(X-ray
1.40A
)
6NBC
(EM
2.80A
)
6NBD
(EM
3.20A
)
6NQ5
(X-ray
1.85A
)
6TB2
(X-ray
2.90A
)
6XD9
(X-ray
2.10A
)
6XDT
(X-ray
1.90A
)
6XE7
(X-ray
2.00A
)
7AET
(X-ray
2.53A
)
7AEU
(X-ray
2.54A
)
7AEV
(X-ray
2.77A
)
7CUE
(X-ray
2.75A
)
7DY3
(X-ray
1.40A
)
7DY4
(X-ray
1.30A
)
7JJQ
(X-ray
2.15A
)
7JXZ
(X-ray
2.23A
)
7JY0
(X-ray
1.63A
)
7JY1
(X-ray
1.59A
)
7JY3
(X-ray
1.48A
)
7PCF
(EM
5.82A
)
7PCH
(EM
2.89A
)
7PCQ
(EM
3.62A
)
7UD7
(X-ray
1.80A
)
7UD8
(X-ray
1.80A
)
7UF6
(X-ray
2.00A
)
7UF7
(X-ray
2.00A
)
7VDE
(EM
3.20A
)
DBSNP
rs33949930
rs33983205
rs713040
rs33983205
rs35906307
rs34769005
rs334
rs33930165
rs33930165
rs334
rs34387455
rs34948328
rs33926764
rs33926764
rs33932981
rs33918131
rs33947457
rs33947457
rs35140348
rs33974228
rs35203747
rs33935445
rs33935445
rs33946157
rs33946157
rs33962676
rs63751285
rs33986703
rs36006214
rs33986703
rs35802118
rs34866629
rs63750840
rs33972047
rs35890959
rs33977536
rs33950093
rs33950093
rs33950093
rs33936254
rs33936254
rs33959855
rs33959855
rs33936254
rs33945546
rs33929459
rs33945546
rs34160180
rs33968721
rs33972975
rs33968721
rs35474880
rs34404985
rs33950507
rs33915112
rs33954632
rs35424040
rs33954632
rs33916412
rs33916412
rs35685286
rs1135071
rs33920173
rs33948578
rs34314652
rs1135101
rs1141387
rs1141387
rs35857380
rs33993004
rs33948615
rs33948615
rs33994623
rs33994623
rs33991059
rs34703513
rs11549407
rs11549407
rs35973315
rs33926796
rs33924146
rs34378160
rs33922842
rs34868397
rs33978338
rs35303218
rs33980484
rs33980484
rs33932070
rs33952850
rs33960931
rs33969727
rs33919924
rs33961886
rs34037627
rs35094013
rs33935983
rs35278874
rs33991472
rs33969400
rs33931779
rs33995148
rs34974709
rs34446260
rs34151786
rs34933455
rs33922873
rs33932548
rs35747961
rs35353749
rs35939489
rs33918343
rs33918343
rs36008922
rs33972593
rs33972593
rs34718174
rs33947415
rs33947415
rs33946401
rs34362537
rs33967755
rs33967755
rs33945705
rs33916541
rs33976006
rs33950542
rs33950542
rs33985847
rs33991294
rs33952543
rs33991294
rs34870172
rs33990858
rs35890380
rs33936967
rs33936967
rs11549406
rs33987903
rs33991993
rs1803195
rs33930385
rs35914488
rs35819837
rs33993568
rs33993568
rs35553496
rs33940204
rs33940204
rs33917628
rs35351128
rs35002698
rs33913712
rs33917785
rs33917785
rs33924775
rs33924775
rs33974325
rs34083951
rs33972927
rs34579351
rs33959340
rs33959340
rs35204496
rs36038739
rs36081208
rs34665886
rs33951978
rs33951978
rs34515413
rs33950993
rs33985510
rs34013622
rs33965000
rs33965000
rs35209591
rs33937393
rs33966487
rs33966487
rs33948057
rs33927739
rs35067717
rs33914944
rs33911434
rs35017910
rs34933751
rs33969677
rs35256489
rs35871407
rs33932908
rs35849199
rs33932908
rs33917394
rs36015961
rs35485099
rs34945623
rs33978082
rs35209776
rs33935673
rs33935673
rs33935527
rs33947020
rs33924134
rs34303736
rs33924134
rs33987957
rs33987957
rs33946267
rs33946267
rs33987957
rs33935383
rs33983276
rs33983276
rs35461710
rs33925391
rs33925391
rs33925391
rs33971634
rs33971634
rs33957286
rs35939430
rs111645889
rs35834416
rs33937535
rs33910209
rs33910209
rs33950778
rs33950778
rs33946775
rs33953406
rs34095019
rs33966761
rs35669628
rs35492035
rs33949486
rs33919821
rs33910475
rs34240441
rs33910475
rs33927093
rs34980264
rs33927093
rs35854892
rs33921821
rs33929415
rs33918338
rs36020563
rs33918338
rs33964352
rs35117167
rs33949869
rs33961444
rs33954264
rs33954264
rs33985739
Subcellular location [CC]
NA
Mouse PG classification
NA
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