| Gene Information | |
|---|---|
| Gene Name | HARS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 509 |
| Protein Names | Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000170445 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P12081 |
| Gene Card | HARS1 |
| Uniprot ID | P12081 |
| Pfam | PF03129; PF13393; PF00458 |
| In ASD | no |
| Allosteric Prediction | yes (0.367876916) |
| Ortholog in Animals | Alpaca_ HARS1 ( ortholog_one2one ) Dog_ HARS1 ( ortholog_one2many ) GuineaPig_ HARS1 ( ortholog_one2one ) Macaque_ HARS1 ( ortholog_one2one ) Mouse_ Hars ( ortholog_one2one ) Pig_ HARS1 ( ortholog_one2one ) Rat_ Hars1 ( ortholog_one2many ) Rabbit_ HARS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HARS2 |
| Tissue | NA |
| Tissue Specificity | Brain, heart, liver and kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1X59 (NMR - ) 2LW7 (NMR - ) 4G84 (X-ray 2.40A ) 4G85 (X-ray 3.11A ) 4PHC (X-ray 2.84A ) 4X5O (X-ray 2.80A ) 5W6M (X-ray 3.70A ) 6O76 (X-ray 2.79A ) |
| DBSNP | rs78741041 rs143473232 rs863225122 rs191391414 rs1239341211 rs863225123 rs147288996 rs536175170 rs1554106881 rs144322728 rs863225124 rs139447495 rs34732372 rs387906639 rs747156884 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:F1Q5D5}. |
| Mouse PG classification | NA |
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