| Gene Information | |
|---|---|
| Gene Name | MID1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 667 |
| Protein Names | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000101871 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15344 |
| Gene Card | MID1 |
| Uniprot ID | O15344 |
| Pfam | PF18568; PF00041; PF13765; PF00622; PF00643; PF13445 |
| In ASD | no |
| Allosteric Prediction | no (-0.111127951) |
| Ortholog in Animals | Alpaca_ MID1 ( ortholog_one2one ) Dog_ MID1 ( ortholog_one2one ) GuineaPig_ MID1 ( ortholog_one2one ) Macaque_ MID1 ( ortholog_one2one ) Mouse_ Mid1 ( ortholog_one2one ) Pig_ MID1 ( ortholog_one2one ) Rat_ Mid1 ( ortholog_one2one ) |
| Ohnologs | MID2, FSD1L, TRIM55, TRIM36 |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | NA |
| Tissue Specificity | In the fetus, highest expression found in kidney, followed by brain and lung. Expressed at low levels in fetal liver. In the adult, most abundant in heart, placenta and brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001615(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DQ5 (NMR - ) 2FFW (NMR - ) 2JUN (NMR - ) 5IM8 (NMR - ) 7QRY (X-ray 2.07A ) |
| DBSNP | rs104894866 rs28934611 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10077590}. Note=Microtubule-associated. It is associated with microtubules throughout the cell cycle, co-localizing with cytoplasmic fibers in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis. |
| Mouse PG classification | LPG |
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