| Gene Information | |
|---|---|
| Gene Name | HAO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 370 |
| Protein Names | 2-Hydroxyacid oxidase 1 (HAOX1) (EC 1.1.3.15) (Glycolate oxidase) (GO) (GOX) (Glyoxylate oxidase) (EC 1.2.3.5) |
| Target Name | hydroxyacid oxidase 1 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000101323 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UJM8 |
| Gene Card | HAO1 |
| Uniprot ID | Q9UJM8 |
| Pfam | PF01070 |
| In ASD | yes |
| Allosteric Prediction | yes (0.630767649) |
| Ortholog in Animals | Alpaca_ HAO1 ( ortholog_one2one ) Dog_ HAO1 ( ortholog_one2one ) GuineaPig_ HAO1 ( ortholog_one2one ) Macaque_ HAO1 ( ortholog_one2one ) Mouse_ Hao1 ( ortholog_one2one ) Pig_ HAO1 ( ortholog_one2one ) Rat_ Hao1 ( ortholog_one2one ) Rabbit_ HAO1 ( ortholog_one2one ) |
| Ohnologs | HAO2 |
| Paralogs | CARNS1, HAO2 |
| Tissue | liver |
| Tissue Specificity | Highly expressed in liver. {ECO:0000269|PubMed:10777549, ECO:0000269|PubMed:10978532}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2NZL (X-ray 1.35A ) 2RDT (X-ray 1.95A ) 2RDU (X-ray 1.65A ) 2RDW (X-ray 1.95A ) 2W0U (X-ray 2.84A ) 5QIB (X-ray 1.48A ) 5QIC (X-ray 1.34A ) 5QID (X-ray 1.45A ) 5QIE (X-ray 1.34A ) 5QIF (X-ray 1.20A ) 5QIG (X-ray 1.42A ) 5QIH (X-ray 1.33A ) 6GMB (X-ray 1.35A ) 6GMC (X-ray 1.20A ) 6W44 (X-ray 1.64A ) 6W45 (X-ray 1.70A ) 6W4C (X-ray 1.75A ) 7M2O (X-ray 2.07A ) 7R4N (X-ray 1.70A ) 7R4O (X-ray 1.50A ) 7R4P (X-ray 1.37A ) |
| DBSNP | NA |
| Subcellular location [CC] | Peroxisome matrix {ECO:0000269|PubMed:10777549}. |
| Mouse PG classification | NA |
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