| Gene Information | |
|---|---|
| Gene Name | PEMPT |
| Organism | Homo sapiens (Human) |
| Gene Length | 199 |
| Protein Names | Phosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (PEMT2) (Phospholipid methyltransferase) (PLMT) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UBM1 |
| Gene Card | PEMT |
| Uniprot ID | Q9UBM1 |
| Pfam | PF04191 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Primarily expressed in liver (at protein level). {ECO:0000269|PubMed:12431977}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs70959686 rs897453 rs897453 rs7946 rs70965427 rs7215880 |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000269|PubMed:15927961}. Note=localized in the endoplasmic reticulum (ER) of the liver and in a lipid metabolism-rich region of the ER known as mitochondria-associated membranes (PubMed:15927961). Adopts a topography within the ER membrane that positions both termini in the cytosol (PubMed:12431977). {ECO:0000269|PubMed:12431977, ECO:0000303|PubMed:15927961}.; [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20860552}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Mitochondrion membrane {ECO:0000255|HAMAP-Rule:MF_03216}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000269|PubMed:12431977}.; [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20860552}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. |
| Mouse PG classification | NA |
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