Gene Information
Gene NameRTN2
OrganismHomo sapiens (Human)
Gene Length545
Protein NamesReticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000125744 )
Evolutionary StageMammalia
AlphaFoldDBO75298
Gene CardRTN2
Uniprot IDO75298
PfamPF02453
In ASDno
Allosteric Predictionno (-0.239610931)
Ortholog in AnimalsAlpaca_ RTN2 ( ortholog_one2one )
Dog_ RTN2 ( ortholog_one2one )
GuineaPig_ RTN2 ( ortholog_one2one )
Macaque_ RTN2 ( ortholog_one2one )
Mouse_ Rtn2 ( ortholog_one2one )
Pig_ RTN2 ( ortholog_one2one )
Rat_ Rtn2 ( ortholog_one2one )
Rabbit_ RTN2 ( ortholog_one2one )
OhnologsNA
ParalogsPRR18, RTN4, RTN1, RTN3
Tissueskeletal.muscle
Tissue Specificity[Isoform RTN2-C]: Highly expressed in skeletal muscle. {ECO:0000269|PubMed:9693037}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs140494585  rs35461805 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:22232211};
Multi-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O70622};
Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q6WN19};
Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:O70622};
Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O70622};
Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O70622}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70622}. Note=Localizes to intermediate filaments in mononucleated myoblasts and to Z lines in mature myotubes. {ECO:0000250|UniProtKB:O70622}.
Mouse PG classificationNA
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