| Gene Information | |
|---|---|
| Gene Name | THEM4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 240 |
| Protein Names | Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000159445 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q5T1C6 |
| Gene Card | THEM4 |
| Uniprot ID | Q5T1C6 |
| Pfam | PF03061 |
| In ASD | no |
| Allosteric Prediction | yes (0.272921816) |
| Ortholog in Animals | Alpaca_ THEM4 ( ortholog_one2one ) Dog_ THEM4 ( ortholog_one2one ) GuineaPig_ THEM4 ( ortholog_one2one ) Mouse_ Them4 ( ortholog_one2one ) Rat_ Them4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | THEM5 |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:15026474}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4AE8 (X-ray 1.59A ) 4GAH (X-ray 2.30A ) |
| DBSNP | rs3748805 rs144257719 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11598301}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11598301}. Cytoplasm {ECO:0000269|PubMed:19604401}. Mitochondrion {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19604401}. Mitochondrion inner membrane; Peripheral membrane protein {ECO:0000269|PubMed:19168129}. Mitochondrion intermembrane space {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19604401}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269|PubMed:19168129}. |
| Mouse PG classification | NA |
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