| Gene Information | |
|---|---|
| Gene Name | ADRB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 477 |
| Protein Names | Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) |
| Target Name | beta-1 adrenergic receptor |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000043591 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08588 |
| Gene Card | ADRB1 |
| Uniprot ID | P08588 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.331194514) |
| Ortholog in Animals | Alpaca_ ADRB1 ( ortholog_one2one ) GuineaPig_ ADRB1 ( ortholog_one2one ) Macaque_ ADRB1 ( ortholog_one2one ) Mouse_ Adrb1 ( ortholog_one2one ) Pig_ ADRB1 ( ortholog_one2one ) Rat_ Adrb1 ( ortholog_one2one ) |
| Ohnologs | HRH2, ADRB2, ADRB3 |
| Paralogs | OR56A4, ADRA2A, ADRB2, ADRA2B, OR56A1, OR56A3, OR56A5, DRD2, ADRA1B, ADRB3, ADRA1D, OR5T2, OR5T3, OR5T1, ADRA1A, GPR101, OR13F1, ADRA2C |
| Tissue | placenta |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2LSQ (NMR - ) 7BTS (X-ray 3.13A ) 7BU6 (X-ray 2.70A ) 7BU7 (X-ray 2.60A ) 7BVQ (X-ray 2.50A ) |
| DBSNP | rs34844626 rs35720093 rs35230616 rs1801252 rs776439595 rs1801253 rs17875445 rs36052953 rs35705839 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P18090}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18090}. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. {ECO:0000250}. |
| Mouse PG classification | NA |
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